Jun 1, 1976

Cardiac histamine receptors

Federation Proceedings
R LeviJ H Zavecz

Abstract

Current evidence pertinent to the identification of cardiac histamine receptors in the guinea pig is reviewed. Pharmacological characterization has been aided by the use of selective agonists and antagonists for both types of histamine receptors. It appears that both H1 and H2 receptors mediate the cardiac effects of histamine. Histamine H2 receptors mediate the positive chronotropic and ventricular inotropic effects. H1 receptors mediate the negative dromotropic effect of histamine and possibly the atrial inotropic effect. Histamine-induced arrhythmias involve H1 receptors (arrhythmias of conduction) or H2 receptors (arrhythmias of automaticity), or both. The receptors mediating the histamine-induced increase in coronary flow are not as clearly defined: both H1 and H2 receptors might be implicated.

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Mentioned in this Paper

Coronary Circulation
Histamine Measurement
Myocardial Contraction
Receptors, Histamine H1
Histamine H2 Receptors
Cavia
Myocardium
Histamine Receptor
Receptors, Drug
Antihistamines, Classical

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