Cardiac hypertrophy: a risk factor for QT-prolongation and cardiac sudden death

Toxicologic Pathology
Y James Kang

Abstract

Cardiac hypertrophy was viewed as a compensatory response to hemodynamic stress. However, cumulative evidence obtained from studies using more advanced technologies in human patients and animal models suggests that cardiac hypertrophy is a maladaptive process of the heart in response to intrinsic and extrinsic stimuli. Although hypertrophy can normalize wall tension, it is a risk factor for QT-prolongation and cardiac sudden death. Studies using molecular biology techniques such as transgenic and knockout mice have revealed many important molecules that are involved in the development of heart hypertrophy and have demonstrated signaling pathways leading to the pathogenesis. With the same approach, the consequence of heart hypertrophy has been examined. The significance of hypertrophy in the development of overt heart failure has been demonstrated and several critical molecular pathways involved in the process were revealed. A comprehensive understanding of the threats of heart hypertrophy to patients has helped to develop novel treatment strategies. The recognition of hypertrophy as a major risk factor for QT-prolongation and cardiac sudden death is an important advance in cardiac medicine. Cellular and molecular mechanisms of ...Continue Reading

References

May 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R E ten EickH H Rasmussen
Jun 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S B McMahon, J G Monroe
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·T EvansG Felsenfeld
Dec 1, 1995·The Journal of Biological Chemistry·A C Newton
Nov 1, 1995·The Journal of Clinical Investigation·W ChengP Anversa
May 1, 1995·Current Opinion in Cardiology·G S Francis, C Chu
Aug 24, 1995·Nature·P B BennettA L George
Jul 1, 1994·The Journal of Cardiovascular Nursing·M R Piano
Oct 1, 1995·Journal of Cardiovascular Electrophysiology·M R Rosen
Apr 12, 1996·Molecular and Cellular Biochemistry·M Pucéat, G Vassort
Jan 1, 1997·Molecular and Cellular Biology·J M LenczowskiJ D Ashwell
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan
Aug 8, 1997·The Journal of Biological Chemistry·T YinJ Whelan
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·J W AdamsG W Dorn
Jan 19, 1999·Annual Review of Cell and Developmental Biology·B L Black, E N Olson
Jan 29, 1999·Physiological Reviews·B Swynghedauw
Nov 2, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M C DelaughterR J Schwartz
Jan 1, 2000·Epidemiology·A PetersD W Dockery
Mar 23, 2000·Cardiovascular Research·C Depre, H Taegtmeyer
Apr 25, 2000·Journal of Molecular and Cellular Cardiology·J D BisognanoD J Port

❮ Previous
Next ❯

Citations

Feb 1, 2011·Cardiovascular Toxicology·Alex P CarllAimen K Farraj
Apr 25, 2012·Cardiovascular Toxicology·Marek SvobodaRostislav Vyzula
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Catharina RuppertKristina Lorenz
Oct 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hongwei JinFadi G Akar
Nov 2, 2007·Clinical and Experimental Pharmacology & Physiology·Hai-Gang ZhangZhi-Bing Yuan
Aug 23, 2012·PLoS Genetics·Christy L AveryKari E North
Mar 27, 2012·Journal of Clinical Biochemistry and Nutrition·Somasundaram ArumugamKenichi Watanabe
Jan 15, 2014·Cardiovascular Research·Yan ZhangHongliang Li
Nov 3, 2010·The American Journal of the Medical Sciences·Chuangjia HuYanyan Li
Jun 10, 2014·Pharmacological Reports : PR·Bhoomika M Patel, Vishal J Desai
Jan 13, 2016·Journal of Chemical Theory and Computation·Dimitar V PachovHenry van den Bedem
May 4, 2010·Journal of Pharmacological and Toxicological Methods·Yaowalak PanyasingRobert L Hamlin
Jun 18, 2010·Clinical Cardiology·Fadi G HageAmi E Iskandrian
Jul 5, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Wei Liang GuJian Ping Gao
Aug 15, 2015·Cardiovascular Research·Romain GuinamardLaurent Sallé
May 26, 2015·Forensic Science International : Synergy·Carl Johan Wingren, Anders Ottosson
May 31, 2006·Gastrointestinal Endoscopy·Panot YimcharoenGlen A Lehman
Nov 21, 2015·Stem Cells Translational Medicine·Benzhi CaiYanjie Lu
May 23, 2014·The Medico-legal Journal·Basappa S HugarAkshith Raj S Shetty
Jun 16, 2016·Molecular BioSystems·Alexandra BrietzThomas Dandekar
Jan 17, 2020·Cardiovascular Endocrinology & Metabolism·Jake Cho, Bosede Afolabi
Apr 7, 2020·The Journal of Veterinary Medical Science·Keisuke ImotoHideyuki Yamawaki
Oct 30, 2020·Frontiers in Psychology·Tudor VrinceanuLouis Bherer
Dec 31, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jung Joo YoonDae Gill Kang

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
transfection
confocal microscopy

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.