Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

American Journal of Obstetrics and Gynecology
C MartinG L Semenza

Abstract

Our purpose was to determine whether the increase in fetal cardiac mass and cardiac output in chronic anemia is accompanied by changes in capillary density or size or changes in levels of vascular endothelial growth factor and hypoxia-inducible factor 1, a basic helix-loop-helix transcription factor that has previously been shown to activate vascular endothelial growth factor gene transcription when cultured cells are subjected to hypoxia. Anemia was induced in near-term ovine fetuses by daily isovolemic hemorrhage. In five fetuses the heart was arrested in diastole, isolated, and fixed at physiologic pressures with adenosine-paraformaldehyde, and morphometric measurements of capillaries were made. In six fetuses cardiac expression of vascular endothelial growth factor and hypoxia-inducible factor 1 protein was detected by Western analysis and vascular endothelial growth factor messenger ribonucleic acid by Northern blot analysis. Eleven age-matched fetuses served as controls. The anemic fetuses compared with controls had a lower hematocrit (14.8% +/- 0.7% vs 35.3% +/- 1.5%) and a greater heart-to-body weight ratio (10.5 +/- 1.1 vs 7.7 +/- 0.5 gm/kg). The minimal capillary diameter was increased and the intercapillary distance ...Continue Reading

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Citations

Aug 31, 2013·Annual Review of Physiology·Gregg L Semenza
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·C H SutterG L Semenza
May 31, 2014·Canadian Journal of Physiology and Pharmacology·Bohuslav OstadalDavid Sedmera
Jan 3, 2001·Journal of Molecular and Cellular Cardiology·R J TorryD S Torry
Jul 12, 2003·High Altitude Medicine & Biology·Loren P Thompson
Oct 31, 1998·Current Opinion in Genetics & Development·G L Semenza
Oct 6, 2000·The Journal of Clinical Investigation·G L Semenza
Jun 13, 2002·Neuropathology and Applied Neurobiology·K L SøndergaardA G Demaine
Nov 12, 2003·Respiratory Physiology & Neurobiology·George L Tipoe, Man-Lung Fung
Jul 23, 1999·Annals of the New York Academy of Sciences·G L SemenzaA Yu
Aug 17, 2010·Acta Pharmacologica Sinica·Demet TekinLei Xi
Dec 28, 1999·Annual Review of Cell and Developmental Biology·G L Semenza
Oct 3, 2002·Annual Review of Medicine·Gregg L Semenza
Dec 22, 1999·Biochemical Pharmacology·G L Semenza
Mar 4, 2000·The New England Journal of Medicine·S H LeeP A Thistlethwaite
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Nov 2, 2016·The Journal of Physiology·Sonnet S JonkerJonathan R Lindner
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