PMID: 9171955Jun 1, 1997Paper

Cardiac hypertrophy in diabetic spontaneously hypertensive rats: role of angiotensin II?

Clinical and Experimental Pharmacology & Physiology
M J BlackC I Johnston

Abstract

1. In the present study the role of angiotensin II (AngII) in the development of cardiac hypertrophy in diabetes combined with hypertension was investigated. 2. Diabetes was induced in 8-week-old male spontaneously hypertensive rats (SHR) by intravenous injection of streptozotocin (45 mg/kg bodyweight). Diabetic SHR were treated with the angiotensin-converting enzyme (ACE) inhibitor ramipril at a dose of 0.4 mg/kg per day. 3. Twelve weeks following the onset of diabetes, hearts were arrested in diastole and were perfusion-fixed. The right ventricle and left ventricle plus septum were weighted and the volume of the ventricular walls was determined using the Cavalieri principle. 4. Induction of diabetes in SHR led to a significant reduction in bodyweight compared with non-diabetic control SHR and this was not affected by ramipril treatment. The development of hypertension was not as great in diabetic SHR compared with controls, such that at 12 weeks following the onset of diabetes systolic blood pressure (SBP) averaged 191 +/- 3 and 230 +/- 4 mmHg in diabetic SHR and controls, respectively. Ramipril treatment significantly lowered SBP in diabetic SHR. 5. The left ventricle plus septum volume:bodyweight ratio (LV vol:BW) was signi...Continue Reading

References

Jul 11, 1992·Journal of the American College of Cardiology·K T WeberC V Leier
Jan 1, 1985·Progress in Cardiovascular Diseases·F S Fein, E H Sonnenblick
Oct 1, 1994·Diabetes·L A SechiM Schambelan
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·M J BlackC I Johnston
Jun 1, 1992·Trends in Cell Biology·J F Bertram, V Nurcombe

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Citations

Jul 11, 2000·Journal of Molecular and Cellular Cardiology·A C RosenkranzR H Ritchie
Sep 15, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mary Jane BlackGeorge Jerums
Jan 16, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Christian MühlfeldTerry M Mayhew
Mar 7, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·W WienenC Audeval-Gerard
Nov 6, 2018·Canadian Journal of Physiology and Pharmacology·Sukhinder K CheemaNaranjan S Dhalla

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