Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B

Proceedings of the National Academy of Sciences of the United States of America
Thomas LangenickelMichael Bader

Abstract

Natriuretic peptides (NP) mediate their effects by activating membrane-bound guanylyl cyclase-coupled receptors A (NPR-A) or B (NPR-B). Whereas the pathophysiological role of NPR-A has been widely studied, only limited knowledge on the cardiovascular function of NPR-B is available. In vitro studies suggest antiproliferative and antihypertrophic actions of the NPR-B ligand C-type NP (CNP). Because of the lack of a specific pharmacological inhibitor, these effects could not clearly be attributed to impaired NPR-B signaling. Recently, gene deletion revealed a predominant role of NPR-B in endochondral ossification and development of female reproductive organs. However, morphological abnormalities and premature death of NPR-B-deficient mice preclude detailed cardiovascular phenotyping. In the present study, a dominant-negative mutant (NPR-BDeltaKC) was used to characterize CNP-dependent NPR-B signaling in vitro and in transgenic rats. Here we demonstrate that reduced CNP- but not atrial NP-dependent cGMP response attenuates antihypertrophic potency of CNP in vitro. In transgenic rats, NPR-BDeltaKC expression selectively reduced NPR-B but not NPR-A signaling. NPR-BDeltaKC transgenic rats display progressive, blood pressure-independen...Continue Reading

References

Nov 1, 1990·The Journal of Clinical Investigation·H ItohV J Dzau
Aug 1, 1972·American Journal of Clinical Pathology·R P Misra
Jul 1, 1997·Cardiovascular Research·H G HutchinsonR E Pratt
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·P M OliverN Maeda
May 15, 1998·Hypertension Research : Official Journal of the Japanese Society of Hypertension·T IgakiK Nakao
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·N MatsukawaO Smithies
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·N TamuraM Katsuki
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·I KishimotoD L Garbers
Nov 16, 2002·Journal of Bone and Mineral Metabolism·Yasato KomatsuKazuwa Nakao
Feb 5, 2003·Cardiovascular Research·Anke C RosenkranzRebecca H Ritchie
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Ji An FengYiu-Fai Chen
Sep 30, 2003·The Journal of Biological Chemistry·Naohisa Tamura, David L Garbers
May 25, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Thomas H LangenickelMichael Bader
Sep 9, 2004·Japanese Heart Journal·Katashi OkoshiAntonio Carlos Cicogna
Dec 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Naohisa TamuraDavid L Garbers
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Volkmar GrossFriedrich C Luft
Mar 22, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Jeetendra B PatelMargaret M Redfield
Apr 5, 2005·Immunopharmacology and Immunotoxicology·Ki-Chan HaSoo-Wan Chae

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Citations

Apr 13, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ines Pagel-LangenickelThomas H Langenickel
Sep 5, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Kazuwa NakaoMasashi Mukoyama
Jun 22, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Speranza RubattuMassimo Volpe
Aug 10, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Camilla CalvieriMassimo Volpe
Dec 4, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Trond BachFinn Olav Levy
Dec 7, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·A J Hobbs
Dec 7, 2007·Nature Cell Biology·Tatjana ShmidtMichael Bader
May 22, 2009·The Journal of Biological Chemistry·Deborah M DickeyLincoln R Potter
Feb 24, 2010·The Journal of Biological Chemistry·Kun WangPei-Feng Li
Oct 23, 2008·The Journal of Biological Chemistry·Deborah M DickeyLincoln R Potter
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Robert LukowskiFranz Hofmann
Jan 1, 2010·Expert Opinion on Drug Discovery·Hirofumi RokutanJochen Springer
Nov 29, 2012·Molecular and Cellular Endocrinology·Xudong ZhuThomas Walther
Jan 19, 2010·Regulatory Peptides·Jens ButtgereitMichael Bader
Sep 3, 2009·Pharmacology & Therapeutics·Rebecca H RitchieBarbara K Kemp-Harper
Jul 28, 2009·Heart Failure Clinics·Torbjørn Omland, Tor-Arne Hagve
Mar 25, 2009·Pharmacology & Therapeutics·Emily J Tsai, David A Kass
Jul 1, 2008·Journal of the American Society of Hypertension : JASH·Kailash N Pandey
Apr 15, 2008·The International Journal of Biochemistry & Cell Biology·Sean P BarryPaul A Townsend
Jan 25, 2008·Progress in Neurobiology·Li-Hui Cao, Xiong-Li Yang
Mar 2, 2016·European Journal of Medical Genetics·Saadullah KhanWasim Ahmad
Mar 30, 2007·Journal of Pharmacological and Toxicological Methods·Pitchai BalakumarManjeet Singh
May 28, 2011·Journal of Cellular Physiology·Xu-Dong XuYong-Wen Qin
May 15, 2015·Clinical and Experimental Pharmacology & Physiology·Christian Binoun-A-EgomEmmanuel E Egom
Mar 17, 2015·Journal of Cardiovascular Translational Research·Emmanuel E Egom
Mar 31, 2015·Cancer Chemotherapy and Pharmacology·Toru KimuraKenji Kangawa
Jun 28, 2008·Journal of the American College of Cardiology·Ondrej LisyJohn C Burnett
Aug 6, 2011·Peptides·Donald F SellittiMaria C Mendonça
Dec 9, 2014·The Journal of Surgical Research·Toru KimuraKenji Kangawa
Jan 20, 2017·Cancer Chemotherapy and Pharmacology·Masahiro ZenitaniKenji Kangawa
Aug 21, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M ÖztopS Turk

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