Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems

American Journal of Physiology. Endocrinology and Metabolism
Wei XiangYan Chun Li

Abstract

Our recent studies suggest that 1,25-dihydroxyvitamin D3 functions as an endocrine suppressor of renin biosynthesis. Genetic disruption of the vitamin D receptor (VDR) results in overstimulation of the renin-angiotensin system (RAS), leading to high blood pressure and cardiac hypertrophy. Consistent with the higher heart-to-body weight ratio, the size of left ventricular cardiomyocytes in VDR knockout (KO) mice was markedly increased compared with wild-type (WT) mice. As expected, levels of atrial natriuretic peptide (ANP) mRNA and circulating ANP were also increased in VDRKO mice. Treatment of VDRKO mice with captopril reduced cardiac hypertrophy and normalized ANP expression. To investigate the role of the cardiac RAS in the development of cardiac hypertrophy, the expression of renin, angiotensinogen, and AT-1a receptor in the heart was examined by real-time RT-PCR and immunostaining. In VDRKO mice, the cardiac renin mRNA level was significantly increased, and this increase was further amplified by captopril treatment. Consistently, intense immunostaining was detected in the left ventricle of captopril-treated WT and VDRKO mice by use of an anti-renin antibody. Levels of cardiac angiotensinogen and AT-1a receptor mRNAs were u...Continue Reading

References

Jan 1, 1992·Annual Review of Physiology·K M BakerD E Dostal
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K R ChienS Chien
Aug 1, 1990·The American Journal of Physiology·K M BakerJ F Aceto
Jun 1, 1987·The Journal of Clinical Investigation·R E Weishaar, R U Simpson
Mar 1, 1993·Clinical and Experimental Pharmacology & Physiology·F NakamuraT Ogihara
Nov 12, 1996·Proceedings of the National Academy of Sciences of the United States of America·E G SheselyO Smithies
Apr 1, 1997·The American Journal of Physiology·T D O'ConnellR U Simpson
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y C LiM B Demay
Apr 8, 1998·The American Journal of Physiology·L J HellerS A Katz
Jul 31, 1998·The New England Journal of Medicine·E R LevinW K Samson
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·R GyurkoP L Huang
Apr 10, 2002·American Journal of Hypertension·Gary PrescottTimothy L Reudelhuber
Jul 11, 2002·Histochemistry and Cell Biology·Cristobal FragaRomán Pérez-Fernández
Mar 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juan Kong, Yan Chun Li
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·Beril TomA H Jan Danser
May 15, 2003·Endocrinology·Julie L Lavoie, Curt D Sigmund
Aug 2, 2003·The New England Journal of Medicine·Ming TengRavi Thadhani
Dec 13, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Tetsuo ShojiYoshiki Nishizawa
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Yan Chun LiJuan Kong

❮ Previous
Next ❯

Citations

Jun 11, 2008·Archives of Internal Medicine·Edward GiovannucciEric B Rimm
Aug 13, 2008·Archives of Internal Medicine·Michal L MelamedBrad Astor
Nov 15, 2012·JAMA : the Journal of the American Medical Association·Gregory P LevinBryan Kestenbaum
Apr 22, 2011·Journal of General Internal Medicine·Kevin FiscellaPeter Franks
Dec 13, 2012·Current Atherosclerosis Reports·Pamela L Lutsey, Erin D Michos
May 10, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Guilin QiaoYan Chun Li
Jan 2, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Myles Wolf, Ravi Thadhani
Feb 6, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Robert U SimpsonKarl A Nibbelink
Dec 2, 2010·Nutrition Research Reviews·Siobhan Muldowney, Mairead Kiely
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Natalya BodyakPeter M Kang
Oct 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zhongyi ZhangYan Chun Li
Oct 3, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nadezda KoleganovaMarie-Luise Gross
Nov 13, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrian CovicDavid Goldsmith
Jun 8, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jorge Rojas-RiveraJesús Egido
Oct 6, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Young Sun KangDae Ryong Cha
May 11, 2005·Kidney International. Supplement·Steven G Achinger, Juan Carlos Ayus
Jun 21, 2011·Seminars in Dialysis·Jason R Stubbs, James B Wetmore
May 7, 2013·Annual Review of Nutrition·Sylvia ChristakosPuneet Dhawan
Jun 17, 2011·Kidney & Blood Pressure Research·Idris GuessousMichel Burnier
Apr 18, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Michal L MelamedPaolo Raggi
Oct 22, 2008·Hypertension·Songcang ChenDavid G Gardner
Jun 27, 2013·Nutrition Journal·Khanh vinh quốc Lu'o'ng, Lan Thi Hoàng Nguyễn
Jun 16, 2011·Endocrinology·Sylvia Christakos, Hector F DeLuca
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Mar 17, 2010·The Journal of Clinical Endocrinology and Metabolism·M D WalkerS J Silverberg
Jul 7, 2012·The Journal of Clinical Endocrinology and Metabolism·Francesco GiallauriaJames Strait
Dec 7, 2011·Journal of Health Care for the Poor and Underserved·Jorge N ArtazaKeith C Norris
Apr 17, 2012·Internal Medicine·Yoshihisa EchidaKosaku Nitta
May 16, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Daniela Veit BarretoZiad A Massy
Dec 24, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Michal L Melamed, Ravi I Thadhani
Apr 18, 2009·Future Cardiology·Erin D Michos
Mar 28, 2009·Journal of Oral Science·Yusuke AmanoMakoto Makishima
Jan 2, 2013·Frontiers in Bioscience (Scholar Edition)·Pandu R GangulaDiane Moseberry
Oct 20, 2012·World Journal of Gastroenterology : WJG·Khanh vinh quốc Lương, Lan Thi Hoàng Nguyễn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.