Cardiac hypertrophy is enhanced in PPAR alpha-/- mice in response to chronic pressure overload

Cardiovascular Research
Pascal J H SmeetsMarc van Bilsen

Abstract

Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a nuclear receptor regulating cardiac metabolism that also has anti-inflammatory properties. Since the activation of inflammatory signalling pathways is considered to be important in cardiac hypertrophy and fibrosis, it is anticipated that PPARalpha modulates cardiac remodelling. Accordingly, in this study the hypothesis was tested that the absence of PPARalpha aggravates the cardiac hypertrophic response to pressure overload. Male PPARalpha-/- and wild-type mice were subjected to transverse aortic constriction (TAC) for 28 days. TAC resulted in a more pronounced increase in ventricular weight and left ventricular (LV) wall thickness in PPARalpha-/- than in wild-type mice. Compared with sham-operated mice, TAC did not affect cardiac function in wild-type mice, but significantly depressed LV ejection fraction and LV contractility in PPARalpha-/- mice. Moreover, after TAC mRNA levels of hypertrophic (atrial natriuretic factor, alpha-skeletal actin), fibrotic (collagen 1, matrix metalloproteinase-2), and inflammatory (interleukin-6, tumour necrosis factor-alpha, cyclo-oxygenase-2) marker genes were higher in PPARalpha-/- than in wild-type mice. The mRNA levels of gene...Continue Reading

References

Oct 1, 1992·Physiological Reviews·G J van der VusseR S Reneman
Sep 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·H A RockmanK R Chien
Aug 1, 1995·The Journal of Clinical Investigation·C M ThaikW S Colucci
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·N H PurcellA Lin
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Esther E J M CreemersFrancis G Spinale
Jan 14, 2003·Annual Review of Physiology·N Frey, E N Olson
Feb 12, 2004·Journal of Molecular and Cellular Cardiology·Quy N DiepErnesto L Schiffrin
May 15, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Yuehua LiChuanfu Li
Jan 25, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Marcello PanagiaKieran Clarke
Mar 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Sudhiranjan GuptaSubha Sen
Sep 2, 2005·Basic Research in Cardiology·Hans DegensMarc van Bilsen
Oct 4, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Yoshihiro HiguchiArthur M Feldman
Jan 31, 2006·Lancet·Lionel H OpieMarc A Pfeffer
Feb 8, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Cécile LoichotRamaroson Andriantsitohaina
Jun 30, 2006·Journal of Molecular and Cellular Cardiology·Sahoko IchiharaMitsuhiro Yokota
Sep 1, 2006·Trends in Endocrinology and Metabolism : TEM·Gabriel Pascual, Christopher K Glass
Mar 21, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Aziz GuellichCatherine Coirault
Apr 7, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Gerhard KrönkeNorbert Leitinger
Oct 16, 2007·Acta Physiologica·P J H SmeetsM van Bilsen

❮ Previous
Next ❯

Citations

Feb 1, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Madhu V Singh, Mark E Anderson
Dec 21, 2011·Cardiovascular Drugs and Therapy·Ting HeMan-Wen Jin
Dec 9, 2008·Antioxidants & Redox Signaling·Milton HamblinY Eugene Chen
Oct 24, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liza MakowskiDeborah M Muoio
May 28, 2011·Clinical and Experimental Pharmacology & Physiology·Jing ChenPing-Jin Gao
Jan 13, 2004·The Journal of the Acoustical Society of America·William M Hartmann, Peter Xinya Zhang
Aug 3, 2000·The Journal of the Acoustical Society of America·F A Bilsen, J Raatgever
Nov 1, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Kristine M Wadosky, Monte S Willis
Oct 3, 2012·PloS One·Ni-Huiping SonRavichandran Ramasamy
Dec 30, 2015·PPAR Research·Christine J PolKonstantinos Drosatos
Dec 10, 2015·PPAR Research·Neerupma SilswalMichael J Wacker
Mar 31, 2015·PPAR Research·Domenick A ProsdocimoMukesh K Jain
May 31, 2016·JCI Insight·Michael A BurkeChristine E Seidman
Aug 5, 2015·PloS One·John TzengShin-Ichi Oka
Sep 2, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Makoto KanekoMitsuaki Isobe
Sep 16, 2016·Journal of Atherosclerosis and Thrombosis·Hsu-Lung JenShing-Jong Lin
Feb 6, 2017·Cardiovascular Research·Elizabeth MurphyJunhui Sun
Jun 25, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Junco Shibayama WarrenJunichi Sadoshima
Sep 2, 2017·Journal of the American Heart Association·Josephine HarringtonElizabeth Murphy
Nov 18, 2015·Circulation Research·Konstantinos DrosatosIra J Goldberg
Jun 18, 2009·European Journal of Clinical Investigation·W P HuangS J Lin
May 28, 2010·Journal of Cardiovascular Pharmacology·Gary D Lopaschuk, Jagdip S Jaswal
Sep 25, 2008·Physiological Genomics·Pascal J H SmeetsMarc van Bilsen
Sep 22, 2010·Expert Opinion on Therapeutic Targets·Marc van Bilsen, Frans A van Nieuwenhoven
Dec 25, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi KaimotoSatoaki Matoba
Nov 25, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Marta ToralRosario Jiménez
Mar 27, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Koichi NishimuraStephen F Vatner
Apr 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mark A ColeKieran Clarke
Nov 8, 2018·International Journal of Molecular Sciences·Zaza KhuchuaSabzali Javadov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.