Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene

Cardiovascular Research
Yilin HaoKazuo Kitamura

Abstract

Osteoprotegerin (OPG) may play a role in the progression of cardiac hypertrophy and heart failure. However, their pathophysiological role in changes in cardiac structure and function with aging remains to be elucidated. We conducted experiments using 2.5- and 12-month-old OPG(-/-) mice and age-matched wild type mice and compared the morphology and function of the left ventricle (LV). Both 2.5- and 12-month-old OPG(-/-) mice showed a higher systolic blood pressure than did age-matched wild type mice, as well as a greater heart weight/body weight ratio. Twelve-month-old OPG(-/-) mice had a significantly larger LV chamber and reduced wall thickness compared to age-matched wild type mice and contractile function was decreased. The morphological differences were accompanied by increase in numbers of apoptotic cells, activation of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) in the LV of 12-month-old OPG(-/-) mice. Correspondingly, OPG siRNA induced the expressions of TRAIL and cleaved caspase-3 in cultured cardiac myocytes. In addition, these mice revealed a decrease in interstitial fibrosis, and activations of matrix metalloproteinase (MMP)-2, tissue inhibitors of MMP-1, -2 with the inactivation of procollagen α1...Continue Reading

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Citations

Aug 9, 2017·Hypertension·Tomasz J Guzik, Rhian M Touyz
Jun 5, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ping-Hsun WuBengt Fellström

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