Cardiac innervation in acute myocardial ischaemia/reperfusion injury and cardioprotection.

Cardiovascular Research
Derek J HausenloyDavid Garcia-Dorado

Abstract

Acute myocardial infarction (AMI) and the heart failure (HF) that often complicates this condition, are among the leading causes of death and disability worldwide. To reduce myocardial infarct (MI) size and prevent heart failure, novel therapies are required to protect the heart against the detrimental effects of acute ischaemia/reperfusion injury (IRI). In this regard, targeting cardiac innervation may provide a novel therapeutic strategy for cardioprotection. A number of cardiac neural pathways mediate the beneficial effects of cardioprotective strategies such as ischaemic preconditioning and remote ischaemic conditioning, and nerve stimulation may therefore provide a novel therapeutic strategy for cardioprotection. In this article, we provide an overview of cardiac innervation and its impact on acute myocardial IRI, the role of extrinsic and intrinsic cardiac neural pathways in cardioprotection, and highlight peripheral and central nerve stimulation as a cardioprotective strategy with therapeutic potential for reducing MI size and preventing HF following AMI. This article is part of a Cardiovascular Research Spotlight Issue entitled 'Cardioprotection Beyond the Cardiomyocyte', and emerged as part of the discussions of the Eu...Continue Reading

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Citations

Mar 25, 2019·Cardiovascular Research·Melanie ZieglerKarlheinz Peter
Dec 28, 2018·Cardiovascular Research·Sean M DavidsonPéter Ferdinandy
May 15, 2020·Cardiovascular Research·Sarah K BrownTomasz J Guzik
May 23, 2020·Journal of Cardiovascular Translational Research·Li YanZhi-Ru Ge
Jul 6, 2020·Nature Reviews. Cardiology·Gerd Heusch
Jun 1, 2021·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Sheng-Feng LuMei-Ling Yu
Jun 15, 2021·Molecular and Cellular Biochemistry·Martín DonatoRicardo J Gelpi
Aug 3, 2021·Frontiers in Cardiovascular Medicine·Natalie N Khalil, Megan L McCain
Jul 10, 2021·Cardiovascular Research·Guido GrassiMurray Esler

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