No abstract listed.
Dose-dependent alteration of rat cardiac sodium current by isoproterenol: results from direct measurements on multicellular preparations
Modulation of the human cardiac sodium channel alpha-subunit by cAMP-dependent protein kinase and the responsible sequence domain
Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel
Isoprostanes as a biomarker of lipid peroxidation in humans: physiology, pharmacology and clinical implications
A quantitative description of membrane current and its application to conduction and excitation in nerve
Cyclosporin and Timothy syndrome increase mode 2 gating of CaV1.2 calcium channels through aberrant phosphorylation of S6 helices
Sodium channel kinetic changes that produce Brugada syndrome or progressive cardiac conduction system disease
Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death
Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias.
Engineering biosynthetic excitable tissues from unexcitable cells for electrophysiological and cell therapy studies.
Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia.
Characterisation of connexin expression and electrophysiological properties in stable clones of the HL-1 myocyte cell line
Effects of the venom of the spider Ornithoctonus hainana on neonatal rat ventricular myocytes cellular and ionic electrophysiology
Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny
The use of ranolazine in non-anginal cardiovascular disorders: A review of current data and ongoing randomized clinical trials
A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current
Ion Fluxes through KCa2 (SK) and Cav1 (L-type) Channels Contribute to Chronoselectivity of Adenosine A1 Receptor-Mediated Actions in Spontaneously Beating Rat Atria
An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel
Geraniol blocks calcium and potassium channels in the mammalian myocardium: useful effects to treat arrhythmias
Influence of Zoledronic Acid on Atrial Electrophysiological Parameters and Electrocardiographic Measurements
The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology
High-throughput identification of off-targets for the mechanistic study of severe adverse drug reactions induced by analgesics
Evaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge
Identification of drug targets related to the induction of ventricular tachyarrhythmia through a systems chemical biology approach
Effective Hypothermic Storage of Human Pluripotent Stem Cell-Derived Cardiomyocytes Compatible With Global Distribution of Cells for Clinical Applications and Toxicology Testing
Rapidly upsloping ST-segment on exercise ECG: a marker of reduced coronary heart disease mortality risk
Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.
Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.
Cardiac Conduction System
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.