Cardiac iron concentration in relation to systemic iron status and disease severity in non-ischaemic heart failure with reduced ejection fraction.

European Journal of Heart Failure
Valentin G HirschTibor Kempf

Abstract

Low cardiac iron levels promote heart failure in experimental models. While cardiac iron concentration (CI) is decreased in patients with advanced heart failure with reduced ejection fraction (HFrEF), CI has never been measured in non-advanced HFrEF. We measured CI in left ventricular (LV) endomyocardial biopsies (EMB) from patients with non-advanced HFrEF and explored CI association with systemic iron status and disease severity. We enrolled 80 consecutive patients with non-ischaemic HFrEF with New York Heart Association class II or III symptoms and a median (interquartile range) LV ejection fraction of 25 (18-33)%. CI was 304 (262-373) μg/g dry tissue. CI was not related to immunohistological findings or the presence of cardiotropic viral genomes in EMBs and was not related to biomarkers of systemic iron status or anaemia. Patients with CI in the lowest quartile (CIQ1 ) had lower body mass indices and more often presented with heart failure histories longer than 6 months than patients in the upper three quartiles (CIQ2-4 ). CIQ1 patients had higher serum N-terminal pro-B-type natriuretic peptide levels than CIQ2-4 patients [3566 (1513-6412) vs. 1542 (526-2811) ng/L; P = 0.005]. CIQ1 patients also had greater LV end-diastolic ...Continue Reading

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Citations

Mar 2, 2021·Deutsche medizinische Wochenschrift·Stefan StörkStefan Frantz
Mar 16, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Patricia PalauJulio Núñez
Oct 10, 2020·European Journal of Heart Failure·Ewa A JankowskaPiotr Ponikowski
Apr 1, 2021·European Journal of Heart Failure·Mohamad F BarakatDarlington O Okonko
Jan 19, 2021·European Journal of Heart Failure·Daniela TomasoniMarco Metra
Jun 17, 2021·European Heart Journal·Tibor Kempf
Jun 18, 2021·Journal of Molecular and Cellular Cardiology·Aleksandra PaterekUrszula Mackiewicz

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