Cardiac iron removal and functional cardiac improvement by different iron chelation regimens in thalassemia major patients

Annals of Hematology
Elena CassinerioMaria Domenica Cappellini

Abstract

Heart failure due to myocardial iron overload remains the leading cause of morbidity and mortality in adult thalassemia major (TM) patients. We evaluated the removal of cardiac iron and the changes of cardiac function by different iron chelation in TM patients by T2* cardiac magnetic resonance (CMR). Sixty-seven TM patients (27 males/40 females; mean age, 35 ± 6 years) on different chelation regimens underwent T2* CMR at baseline (t (0)), after 6-14 months (t (1)) and after 32 ± 7 months (t (2)). Patients were divided in four groups according to chelation treatment: group A (deferasirox), group B (deferoxamine), group C (combined treatment, deferoxamine plus deferiprone) and group D (deferiprone alone). Myocardial T2* at t (0) was <10 ms in 8 patients, between 10 and 20 ms in 22 patients and ≥ 20 ms in 37 patients. Progressive changes in T2* were observed at t (1) and t (2). Ten patients (10/36, 27.8 %) in group A, three patients (3/15, 20 %) in group B and three patients (3/12, 25 %) in group C moved from an abnormal T2* to normal values. We observed an improvement of left ventricular ejection fraction and a reduction of end-systolic and end-diastolic left ventricular volumes only in patients in group A with baseline cardiac T...Continue Reading

References

Sep 1, 1994·The New England Journal of Medicine·G M BrittenhamJ W Harris
Sep 22, 2005·The International Journal of Cardiovascular Imaging·Mark A WestwoodDudley J Pennell
Dec 17, 2009·Hemoglobin·Maria D CappelliniAli T Taher
Jun 9, 2010·Hemoglobin·Charalampos Pontikoglou, Helen A Papadaki
Feb 1, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Giorgio DerchiGian Luca Forni

❮ Previous
Next ❯

Citations

Jul 1, 2014·British Journal of Haematology·Antonio PigaMaria Domenica Cappellini
Jun 26, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Benedikt SchaeferHeinz Zoller
Jan 17, 2013·Hematology·Vedat Uygun, Erdal Kurtoglu
Jan 28, 2018·Journal of Medical Case Reports·Shamil D CoorayStuart K Roberts
Aug 22, 2013·The Cochrane Database of Systematic Reviews·Sheila A FisherDavid J Roberts
Aug 24, 2013·The Cochrane Database of Systematic Reviews·Sheila A FisherDavid J Roberts
Mar 16, 2017·British Journal of Haematology·Thomas D Coates, John C Wood
May 13, 2020·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·G J H SnelN H J Prakken

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.