Cardiac Lymphatic Dysfunction Causes Drug-Eluting Stent-Induced Coronary Hyperconstricting Responses in Pigs In Vivo

Arteriosclerosis, Thrombosis, and Vascular Biology
Hirokazu AmamizuHiroaki Shimokawa

Abstract

Objective- We have previously demonstrated that coronary adventitial inflammation plays important roles in the pathogenesis of coronary vasomotion abnormalities, including drug-eluting stent (DES)-induced coronary hyperconstricting responses. Importantly, the adventitia also harbors lymphatic vessels, which may prevent inflammation by transporting extravasated fluid and inflammatory cells. We thus aimed to examine the roles of coronary adventitial lymphatic vessels in the pathogenesis of DES-induced coronary hyperconstricting responses in a porcine model in vivo. Approach and Results- We performed 2 experimental studies. In protocol 1, 15 pigs were divided into 3 groups with or without DES and with bare metal stent. Nonstented sites 20 mm apart from stent implantation also were examined. In the protocol 2, 12 pigs were divided into 2 groups with or without lymphatic vessels ligation followed by DES implantation at 2 weeks later (n=6 each). We performed coronary angiography 4 weeks after DES implantation, followed by immunohistological analysis. In protocol 1, the number and the caliber of lymphatic vessels were greater at only the DES edges after 4 more weeks. In protocol 2, coronary hyperconstricting responses were further enh...Continue Reading

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Citations

Oct 22, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Yijiang ZhouXiaosheng Hu
Mar 26, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Shigeo GodoHiroaki Shimokawa
Jun 12, 2021·European Heart Journal. Case Reports·Takuya NakamuraHiroyuki Kawata
Nov 30, 2021·Journal of Cardiovascular Pharmacology·Shigeo GodoHiroaki Shimokawa

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