Cardiac magnetic resonance imaging study for quantification of infarct size comparing directly serial versus single time-point measurements of cardiac troponin T

Journal of the American College of Cardiology
E GiannitsisH A Katus

Abstract

We compared single-point cardiac troponin T (cTnT) measurements with parameters from serial sampling during 96 h after acute myocardial infarction with magnetic resonance imaging measured infarct mass. Contrast-enhanced magnetic resonance imaging (CE-MRI) allows exact quantification of myocardial infarct size. Clinically, measurement of cardiac biomarkers is a more convenient alternative. The CE-MRI infarct mass was determined 4 days after primary percutaneous coronary intervention in 31 ST-segment elevation myocardial infarction (STEMI) and 30 non-ST-segment elevation myocardial infarction (NSTEMI) patients. All single-point, peak, and integrated area under the curve (AUC) cTnT values were plotted against CE-MRI infarct mass. All single-point and serial cTnT values were significantly higher in STEMI than in NSTEMI (p < 0.01) patients. Except for the admission values, all single-point values on any of the first 4 days, peak cTnT and AUC cTnT were found to correlate comparably well with infarct mass. Among single-point measurements, cTnT on day 4 (cTnTD4) showed highest correlation and performed as well as peak cTnT or AUC cTnT (r = 0.66 vs. r = 0.65 vs. r = 0.69). Receiver-operator characteristic analysis demonstrated that cTnT...Continue Reading

References

Apr 1, 1978·The Journal of Clinical Investigation·S F VatnerP R Maroko
Aug 1, 1975·British Heart Journal·S A WitteveenW T Hermens
Nov 1, 1975·Circulation·R RobertsB E Sobel
Aug 14, 1986·The New England Journal of Medicine·M A DeWoodM L Hinnen
Aug 11, 1983·The New England Journal of Medicine·UNKNOWN Multicenter Postinfarction Research Group
Jun 1, 1997·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·J A KragtenM P van Dieijen-Visser
Apr 12, 2000·Journal of the American College of Cardiology·B E Sobel, M M LeWinter
Oct 19, 2004·Journal of the American College of Cardiology·Raymond J GibbonsAllan S Jaffe
Dec 13, 2006·Journal of the American College of Cardiology·Henning SteenHugo A Katus
Feb 3, 2007·Radiology·Elizabeth A SadowskiArjang Djamali

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Citations

Nov 1, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Kerstin KurzEvangelos Giannitsis
Jul 8, 2009·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Mirja NeizelHugo A Katus
Aug 6, 2010·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of the ESC Working Group on Acute Cardiac Care
Dec 21, 2010·European Heart Journal·S AgewallH Katus
Jul 22, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael E DunnWanping Geng
Jul 30, 2009·Nuclear Medicine Communications·Ismail DoganOmer Turker
Jul 30, 2011·Future Cardiology·Jonathan W Waks, Benjamin M Scirica
Mar 4, 2014·International Journal of Environmental Research and Public Health·Xiakun ZhangPinwen Guo
May 2, 2014·The International Journal of Cardiovascular Imaging·Elena GuerraAdnan Kastrati
Dec 8, 2014·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·André LuzSevero Torres
Dec 1, 2010·Scandinavian Cardiovascular Journal : SCJ·Carl Gunnar Gustavsson, Margareta Nilson
Jan 30, 2016·Journal of the American College of Cardiology·Filippo OttaniUNKNOWN CYCLE Investigators
Feb 16, 2013·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Arnt V KristenStefan E Hardt
Feb 16, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Simona FerraroAngelo S Bongo
Nov 26, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mauro Panteghini, Jillian R Tate
Sep 24, 2015·International Journal of Cardiology·Sebastian Johannes ReinstadlerBernhard Metzler
May 8, 2009·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Milos KesekUrban Wiklund
Oct 18, 2013·Veterinary Clinical Pathology·Rebecca LanghornMads Kjelgaard-Hansen
Dec 9, 2008·American Heart Journal·Adelaide M Arruda-OlsonVéronique L Roger
Mar 10, 2009·The American Journal of Cardiology·Grigorios KorosoglouHugo A Katus

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