Cardiac malformations are increased in infants of mothers with epilepsy

Pediatric Cardiology
S V ThomasP S Sarma

Abstract

We aimed to ascertain the prevalence of cardiac malformation (CM) and its association with antenatal exposure to an antiepileptic drug (AED) in infants of mothers with epilepsy (IMEs). Women with epilepsy (WWE) are enrolled in Kerala Registry of Epilepsy and Pregnancy (KREP) in the prepregnancy or early pregnancy period and are followed up with a standard protocol until the IMEs are 6 years old. At 3 months postpartum, a cardiologist, blinded to the AED exposure, carried out a clinical examination and echocardiography on all live-born babies. Patent foramen ovale (PFO) and interatrial septal defects of < 5 mm in size were excluded from CM. Details of maternal epilepsy, folate usage, AED exposure in the first trimester, and newborn characteristics were abstracted from the records of the KREP. We examined 462 babies. Maternal epilepsy was generalized in 201 (43.50%) or localization related in 241 (52.2%). The AED exposure was monotherapy in 262 (56.7%)--carbamazepine (112), valproate (71), phenobarbitone (43), phenytoin (31), and clonazepam (2)--and polytherapy in 126 (27.3%). Seventy-four infants (16.01%) had no AED exposure. There were 36 infants with CM (7.8%; 95% confidence interval: 5.5-10.6). CMs included atrial septal defe...Continue Reading

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Citations

Sep 13, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A VereczkeyI Szabó
Aug 7, 2013·Seminars in Perinatology·Laura A Hart, Baha M Sibai
Aug 15, 2013·Pediatric Cardiology·Ayse Esin KibarFusun Dilara Içağasıoğlu
Dec 5, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Melinda Csáky-SzunyoghAndrew E Czeizel
Feb 1, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Betül Tekin GüveliCandan Gürses
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Jun 20, 2012·American Journal of Medical Genetics. Part a·Bogdan J WlodarczykRichard H Finnell
Mar 27, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Shahla ShojaeiHagar I Labouta

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