PMID: 12154418Aug 3, 2002Paper

Cardiac marker responses to coronary artery bypass graft surgery with cardiopulmonary bypass and aortic cross-clamping

Journal of Cardiothoracic and Vascular Anesthesia
Shinhiro TakedaRyo Ogawa


To study several markers of myocardial injury in relation to aortic cross-clamping and cardiopulmonary bypass (CPB) after coronary artery bypass graft (CABG) surgery. Prospective observational study. University hospital. Thirty adult patients who underwent elective CABG surgery with aortic cross-clamping and CPB. Serum levels of interleukin-6 (IL-6), interleukin-8 (IL-8), troponin-T (TnT), myosin light chain I (MLCI), and MB isoenzyme of creatine kinase (CK-MB), as markers of myocardial injury, were measured after induction of anesthesia for baseline values, then again at the end of surgery and on postoperative days 1, 3, and 5. IL-6, IL-8, and CK-MB levels were significantly elevated in the early postoperative stage. TnT significantly increased from the end of surgery to postoperative day 5. MLCI increased also but later than TnT. Aortic cross-clamping time correlated positively with peak TnT (r = 0.51, p < 0.05), TnT level on postoperative day 1 (r = 0.69, p < 0.01), and MLCI level on postoperative day 5 (r = 0.45, p < 0.05). CPB time was correlated only with peak TnT (r = 0.47, p < 0.05). The increase in TnT level is strongly related to aortic cross-clamping.


Jan 1, 2004·Indian Journal of Clinical Biochemistry : IJCB·Javad MohitiAli Babaei
Apr 8, 2011·Asian Cardiovascular & Thoracic Annals·Vladimir V LomivorotovAlexander M Karaskov
Dec 15, 2011·The Heart Surgery Forum·Vladimir V LomivorotovAlexander M Karaskov
Jan 9, 2019·Frontiers in Cardiovascular Medicine·Hendrik T Tevaearai StahelThierry P Carrel
Aug 1, 2007·Asian Cardiovascular & Thoracic Annals·Madan M Maddali, Muthukkumar C Rajakumar
Feb 16, 2018·Interactive Cardiovascular and Thoracic Surgery·Benedikte T SmenesAlexander Wahba

Related Concepts

MLC1SA protein, human
Ascending Aorta Structure
Coronary Artery Bypass Surgery
Cardiopulmonary Bypass
Closure by Clamp
Macro-Creatine Kinase
Myocardial Infarction
Receiver Operating Characteristic
Viral Markers

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