Cardiac mechano-electric feedback and electrical restitution in humans

Progress in Biophysics and Molecular Biology
Peter Taggart, M J Lab

Abstract

Electrical restitution in the heart is the property whereby the action potential duration and conduction velocity of a beat of altered cycle length vary according to its immediacy to the preceding basic beat--the coupling interval, usually the diastolic interval. In general, action potential duration (APD) increases with increasing coupling interval, and the relation between action potential duration and the preceding diastolic interval describes the APD restitution curve. The latter has recently been the focus of considerable interest since the steepness of the initial part of the restitution curve plays an important role in electrical stability and arrhythmogenesis. Mechanical stretch has been shown to alter APD and hence refractoriness either through stretch activated channels or by influencing calcium cycling. Such an effect on refractoriness has been proposed as a mechanism of arrhythmogenesis particularly if spatially inhomogeneities manifest within the heart. Here, we review (1) the spatial and temporal characteristics of APD restitution in humans; (2) previously reported work showing that mechanical loading differentially effects APD of interpolated beats of altered cycle length, and hence alters the slope of the APD re...Continue Reading

References

Aug 1, 1968·Journal of Applied Physiology·J B Nolasco, R W Dahlen
Mar 17, 1999·Circulation·J M PastoreD S Rosenbaum
Aug 31, 1999·Journal of Cardiovascular Electrophysiology·R F Gilmour, D R Chialvo
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·A GarfinkelP S Chen
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·F XieJ N Weiss
Mar 10, 2001·Journal of Cardiovascular Electrophysiology·M A WatanabeA Karma
Apr 20, 2001·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·F XieA Garfinkel
Dec 12, 2002·Journal of Cardiovascular Electrophysiology·Robert F Gilmour
Dec 12, 2002·Journal of Cardiovascular Electrophysiology·Raymond E IdekerRichard A Gray
Jan 23, 2003·Circulation·Peter TaggartJaswinder S Gill
Jan 1, 1964·Circulation Research·J HAN, G K MOE
Feb 6, 2004·Journal of Cardiovascular Electrophysiology·Michael R Franz
Sep 20, 2005·Journal of the American College of Cardiology·Arthur M YueJohn M Morgan
Nov 30, 2006·Annals of the New York Academy of Sciences·Max J Lab
Jun 15, 2007·Circulation·Darwin JeyarajDavid S Rosenbaum
Aug 16, 1991·Science·F SachsC Bowman
Apr 9, 2008·Progress in Biophysics and Molecular Biology·Kenneth R Laurita, David S Rosenbaum
Apr 15, 2008·Progress in Biophysics and Molecular Biology·Paulus KirchhofLarissa Fabritz

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Citations

Mar 14, 2003·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·S LévyUNKNOWN Working Group on Arrhythmias, Working Group on Cardiac Pacing of the European Society of Cardiology, North American Society
Nov 1, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michael R FranzSanjiv M Narayan
Mar 17, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Yanggan WangBrian H Crawford
Nov 19, 2014·Global Cardiology Science & Practice·Alistair ReedRémi Peyronnet
Feb 24, 2015·Cardiology in the Young·Louis-Simon BeauséjourDaniel Curnier
Mar 10, 2012·Journal of Biomechanics·Tatyana F ShklyarFelix A Blyakhman
Feb 4, 2011·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Andrea GladuliNiels F Otani
Apr 9, 2008·Progress in Biophysics and Molecular Biology·Kenneth R Laurita, David S Rosenbaum
Apr 4, 2008·Progress in Biophysics and Molecular Biology·D S LoiselleC J Barclay
Apr 12, 2008·Progress in Biophysics and Molecular Biology·Tammo DelhaasTheo Arts
Jul 14, 2009·Experimental Physiology·Haixia HuangWeizhen Niu
May 4, 2015·Cardiovascular Research·Tobias OpthofRuben Coronel
Jan 26, 2010·Journal of Molecular and Cellular Cardiology·Yanggan Wang, Joseph A Hill
Jan 26, 2010·Journal of Molecular and Cellular Cardiology·Sabine Huke, Björn C Knollmann
Apr 10, 2010·Journal of Electrocardiology·Linyuan JingAbhijit Patwardhan
Jun 7, 2014·Journal of Zhejiang University. Science. B·Jun-xian CaoFan Qu
Nov 11, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Karl-Jonas AxelssonLennart Bergfeldt
Apr 16, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Matthew F PizzutoJohn M Canty
Mar 8, 2017·Pflügers Archiv : European journal of physiology·Karan R ChaddaChristopher L-H Huang
Dec 29, 2020·Frontiers in Physiology·Viviane Timmermann, Andrew D McCulloch
Apr 15, 2008·Progress in Biophysics and Molecular Biology·Peter Kohl, Denis Noble
Dec 25, 2016·Computers in Biology and Medicine·Akshay Kota Aswath KumarVincent Jacquemet

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