Cardiac Mechano-Gated Ion Channels and Arrhythmias

Circulation Research
Rémi PeyronnetPeter Kohl


Mechanical forces will have been omnipresent since the origin of life, and living organisms have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The cardiovascular system in general, and the heart in particular, is exposed to constantly changing mechanical signals, including stretch, compression, bending, and shear. The heart adjusts its performance to the mechanical environment, modifying electrical, mechanical, metabolic, and structural properties over a range of time scales. Many of the underlying regulatory processes are encoded intracardially and are, thus, maintained even in heart transplant recipients. Although mechanosensitivity of heart rhythm has been described in the medical literature for over a century, its molecular mechanisms are incompletely understood. Thanks to modern biophysical and molecular technologies, the roles of mechanical forces in cardiac biology are being explored in more detail, and detailed mechanisms of mechanotransduction have started to emerge. Mechano-gated ion channels are cardiac mechanoreceptors. They give rise to mechano-electric feedback, thought to contribute to normal function, disease development, and, potentially, therapeutic interventions. In this review, w...Continue Reading


Jun 3, 1976·The New England Journal of Medicine·P M ZollH A Frank
Sep 11, 1992·Pflügers Archiv : European journal of physiology·D W McBride, O P Hamill
Dec 1, 1992·The Journal of General Physiology·D Kim
Jan 1, 1992·Experimental Physiology·P KohlT Streubel
Jul 1, 1988·Biophysical Journal·L L Stockbridge, A S French
Oct 1, 1989·Journal of Applied Physiology·L BernardiM R Pinsky
Oct 1, 1988·Bioscience Reports·W CraeliusN el-Sherif
Jan 1, 1994·Biophysical Journal·L R Opsahl, W W Webb
May 1, 1993·Experimental Physiology·W Craelius
Feb 1, 1993·Journal of Cardiovascular Electrophysiology·C RipollC G Nichols
Jun 1, 1993·Journal of Biomechanics·J H OmensA D McCulloch
Jul 1, 1996·Cardiovascular Research·J I VandenbergT Powell
Jul 1, 1996·Cardiovascular Research·I KiselevaM J Lab
Apr 29, 1998·Reviews of Physiology, Biochemistry and Pharmacology·F Sachs, C E Morris
Jun 5, 1998·Clinical and Experimental Pharmacology & Physiology·D P SlovutJ H Abrams
Jun 19, 1998·The New England Journal of Medicine·M S LinkN A Estes
Aug 4, 1998·The EMBO Journal·A J PatelM Lazdunski
Aug 4, 1998·The American Journal of Physiology·R A CaldwellC M Baumgarten
Mar 10, 1999·Progress in Biophysics and Molecular Biology·P KohlD Noble
May 13, 1999·Nature Neuroscience·A J PatelM Lazdunski
Jul 29, 1999·Biophysical Journal·I V TabareanC E Morris
Oct 8, 1999·Biophysical Journal·D Raucher, M P Sheetz
Feb 10, 2000·The Journal of Membrane Biology·G C Bett, F Sachs
Feb 10, 2000·The Journal of Membrane Biology·G C Bett, F Sachs
Feb 13, 2001·Brain Research. Molecular Brain Research·A D MedhurstM N Pangalos

❮ Previous
Next ❯


Jan 19, 2016·Trends in Molecular Medicine·Eva A Rog-ZielinskaRoger Markwald
Jun 25, 2016·Nature Reviews. Drug Discovery·Robert G GourdiePeter Kohl
Dec 25, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·T Alexander Quinn, Peter Kohl
Mar 17, 2017·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Hideki HayashiMinoru Horie
Jun 27, 2017·Progress in Biophysics and Molecular Biology·Patrick SchönleitnerGudrun Antoons
Jan 10, 2018·Frontiers in Cardiovascular Medicine·Leah A Pagnozzi, Jonathan T Butcher
Jan 8, 2019·Acta Physiologica·Jarrah M DowrickMarie-Louise Ward
Apr 26, 2019·Journal of Cellular and Molecular Medicine·Bin FangQingfeng Li
Jan 7, 2018·Herzschrittmachertherapie & Elektrophysiologie·Constanze Schmidt, Rémi Peyronnet
Mar 6, 2018·The Tohoku Journal of Experimental Medicine·Wenyu HuJian Hu
Dec 4, 2019·The Journal of Physiology·Leighton T IzuYe Chen-Izu
May 28, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Simon J WilsonColm G Hanratty
May 23, 2020·Journal of Cardiovascular Development and Disease·Neha AhujaDeborah Garrity
Aug 1, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Aurore LyonJoost Lumens
Sep 19, 2019·Biophysics Reviews·Julia VerheyenRémi Peyronnet
Feb 25, 2017·Biological cybernetics·Q X MaF Argoul
Jul 21, 2017·Channels·Ehsan Nematian-ArdestaniStephen J Tucker
Nov 8, 2018·Journal of Clinical Medicine·Tzyy-Yue WongPei-Wen Cheng
Jul 14, 2018·Scientific Reports·Hanyu ZhangJack M Rogers
Mar 4, 2020·The Journal of Biological Chemistry·Alexandria O MiltonShetuan Zhang
Jun 6, 2018·Cardiovascular Toxicology·Luis Such-MiquelFrancisco J Chorro
Sep 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Michael V ClausenStephen J Tucker
Dec 8, 2017·Herzschrittmachertherapie & Elektrophysiologie·Jordi Heijman, Dobromir Dobrev
Jan 27, 2019·Nature Reviews. Cardiology·Jeffrey J SaucermanJeffrey H Omens
Sep 3, 2018·Cardiovascular Drugs and Therapy·Irene Del CantoFrancisco J Chorro
Nov 27, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Robin AndlauerAxel Loewe
Aug 28, 2020·Frontiers in Physiology·Irene Del-CantoAndreu M Climent
Jun 13, 2020·Frontiers in Physiology·Mark G HoogendijkTamas Szili-Torok
Oct 11, 2019·Journal of the American Heart Association·Yuriy V EgorovAlexey V Glukhov
Feb 20, 2020·The Journal of Physiological Sciences : JPS·Nathalie A Balakina-VikulovaLeonid B Katsnelson
Mar 30, 2020·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Stefania Angela Di FuscoMassimo Santini
Nov 16, 2019·Pflügers Archiv : European journal of physiology·Michele MaroniEsther Eberhardt
Nov 11, 2020·Annals of Biomedical Engineering·Zachary E GoldblattKristen L Billiar
Nov 25, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Hina EmanuelCindy Jon
Dec 29, 2020·Frontiers in Physiology·Viviane Timmermann, Andrew D McCulloch
Jan 2, 2021·Frontiers in Physiology·Hannah E BoycottPaul Robinson
Jul 6, 2020·Progress in Biophysics and Molecular Biology·Johann P Kuhtz-BuschbeckWilhelm T Wolze
Oct 15, 2020·Progress in Biophysics and Molecular Biology· Marta VarelaJack Lee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Homeostasis

Cardiovascular regulation and homeostasis is important in maintaining health and dysfunction may lead to cardiovascular diseases. Nitric oxide and vascular endothelium are one of many molecules involved in the homeostatic mechanism. Here is the latest research on cardiovascular homeostasis.

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.


Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Related Papers

Global Cardiology Science & Practice
Alistair ReedRémi Peyronnet
Journal of Cellular and Molecular Medicine
Ken TakahashiKeiji Naruse
Biochimica Et Biophysica Acta
Andrew E EkpenyongJochen Guck
© 2022 Meta ULC. All rights reserved