Mechanical forces will have been omnipresent since the origin of life, and living organisms have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The cardiovascular system in general, and the heart in particular, is exposed to constantly changing mechanical signals, including stretch, compression, bending, and shear. The heart adjusts its performance to the mechanical environment, modifying electrical, mechanical, metabolic, and structural properties over a range of time scales. Many of the underlying regulatory processes are encoded intracardially and are, thus, maintained even in heart transplant recipients. Although mechanosensitivity of heart rhythm has been described in the medical literature for over a century, its molecular mechanisms are incompletely understood. Thanks to modern biophysical and molecular technologies, the roles of mechanical forces in cardiac biology are being explored in more detail, and detailed mechanisms of mechanotransduction have started to emerge. Mechano-gated ion channels are cardiac mechanoreceptors. They give rise to mechano-electric feedback, thought to contribute to normal function, disease development, and, potentially, therapeutic interventions. In this review, w...Continue Reading
Stretch-activated non-selective cation channels in the antiluminal membrane of porcine cerebral capillaries
Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation
A new method of attachment of isolated mammalian ventricular myocytes for tension recording: length dependence of passive and active tension
Evidence for an intrinsic mechanism regulating heart rate variability in the transplanted and the intact heart during submaximal dynamic exercise?
Magnetic fields applied to collagen-coated ferric oxide beads induce stretch-activated Ca2+ flux in fibroblasts
Streptomycin reverses a large stretch induced increases in [Ca2+]i in isolated guinea pig ventricular myocytes
Stretch-induced voltage changes in the isolated beating heart: importance of the timing of stretch and implications for stretch-activated ion channels
A possible mechanism for large stretch-induced increase in [Ca2+]i in isolated guinea-pig ventricular myocytes
Biological adaptation of the myocardium to chronic mechanical overload. Molecular determinants of the autonomic nervous system
Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli
Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical models
Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels
Simultaneous activation of p38 MAPK and p42/44 MAPK by ATP stimulates the K+ current ITREK in cardiomyocytes
Selected contribution: axial stretch increases spontaneous pacemaker activity in rabbit isolated sinoatrial node cells
Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery
Comparing maximum rate and sustainability of pacing by mechanical vs. electrical stimulation in the Langendorff-perfused rabbit heart
Sudden cardiac death: the pro-arrhythmic interaction of an acute loading with an underlying substrate
Quantitative systems models illuminate arrhythmia mechanisms in heart failure: Role of the Na+ -Ca2+ -Ca2+ /calmodulin-dependent protein kinase II-reactive oxygen species feedback.
In Vivo Post-Cardiac Arrest Myocardial Dysfunction Is Supported by Ca2+/Calmodulin-Dependent Protein Kinase II-Mediated Calcium Long-Term Potentiation and Mitigated by Alda-1, an Agonist of Aldehyde Dehydrogenase Type 2
Mechanically Induced Ectopy via Stretch-Activated Cation-Nonselective Channels Is Caused by Local Tissue Deformation and Results in Ventricular Fibrillation if Triggered on the Repolarization Wave Edge (Commotio Cordis)
The effects of mechanical stretch on the biological characteristics of human adipose-derived stem cells
Voltage-gated and stretch-activated potassium channels in the human heart : Pathophysiological and clinical significance
Incidence of "shocktopics" and asynchronous cardiac pacing in patients undergoing coronary intravascular lithotripsy
Differentiating the effects of β-adrenergic stimulation and stretch on calcium and force dynamics using a novel electromechanical cardiomyocyte model
The Lectin LecA Sensitizes the Human Stretch-Activated Channel TREK-1 but Not Piezo1 and Binds Selectively to Cardiac Non-myocytes
Targeting Cardiac Myocyte Na+-K+ Pump Function With β3 Adrenergic Agonist in Rabbit Model of Severe Congestive Heart Failure.
Mechanical stretch increases Kv1.5 current through an interaction between the S1-S2 linker and N-terminus of the channel.
Effects of the Inhibition of Late Sodium Current by GS967 on Stretch-Induced Changes in Cardiac Electrophysiology
Influence of left atrial size on P-wave morphology: differential effects of dilation and hypertrophy
Caveolae-Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis
Mechano-calcium and mechano-electric feedbacks in the human cardiomyocyte analyzed in a mathematical model
Effects of mechanical feedback on the stability of cardiac scroll waves: A bidomain electro-mechanical simulation study
Report on the Ion Channel Symposium : Organized by the German Cardiac Society Working Group on Cellular Electrophysiology (AG 18)
Mechanoelectrical feedback in pulmonary vein arrhythmogenesis: Clinical challenges and therapeutic opportunities
Cardiac Mechano-Electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm.
Differences in Gating Dynamics of BK Channels in Cellular and Mitochondrial Membranes from Human Glioblastoma Cells Unraveled by Short- and Long-Range Correlations Analysis.
Cardiac arrhythmias associated with volume-assured pressure support mode in a patient with autonomic dysfunction and mitochondrial disease.
Mechano-Electric Coupling and Arrhythmogenic Current Generation in a Computational Model of Coupled Myocytes.
The origin of the heartbeat and theories of muscle contraction. Physiological concepts and conflicts in the 19th century.
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