Cardiac mechanotransduction: from sensing to disease and treatment

Trends in Pharmacological Sciences
P TaviH Ruskoaho

Abstract

In heart muscle a mechanical stimulus is sensed and transformed into adaptive changes in cardiac function by a process called mechanotransduction. Adaptation of heart muscle to mechanical load consists of neurohumoral activation and growth, both of which decrease the initial load. Under prolonged overload this process becomes maladaptive, leading to the development of left ventricular hypertrophy and ultimately to heart failure. Widespread synergism and crosstalk among a variety of molecules and signals involved in hypertrophic signaling pathways make the prevention or treatment of left ventricular hypertrophy and heart failure a challenging task. Therapeutic strategies should include either a complete and continuous reduction of load or normalization of left ventricular mass by interventions aimed at specific targets involved in mechanotransduction.

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Jul 1, 1994·Circulation Research·G McClellanS Winegrad
Jan 1, 1993·Annual Review of Physiology·K R ChienS M Evans
Oct 1, 1995·Cardiovascular Research·P H Sugden, M A Bogoyevitch
Jan 1, 1997·Annual Review of Physiology·J Sadoshima, S Izumo
Jan 1, 1997·Annual Review of Immunology·A RaoP G Hogan
Dec 31, 1997·The Journal of Clinical Investigation·J C BowmanP M Buttrick
Jun 10, 1998·Journal of Molecular and Cellular Cardiology·C F VahlS Hagl
Jun 11, 1998·Developmental Genetics·D Durocher, M Nemer
Jul 31, 1998·The New England Journal of Medicine·E R LevinW K Samson
Oct 15, 1998·Nature Medicine·Z LuoK Walsh
Jan 29, 1999·Physiological Reviews·B Swynghedauw
Apr 3, 1999·Circulation Research·P H Sugden
Jun 4, 1999·Seminars in Cell & Developmental Biology·F Charron, M Nemer
Jul 30, 1999·Biochemical and Biophysical Research Communications·Z WuC A McCulloch
Oct 21, 1999·The New England Journal of Medicine·J J Hunter, K R Chien
Dec 22, 1999·Acta Physiologica Scandinavica·P TaviM Weckström
Jan 20, 2000·The New England Journal of Medicine·UNKNOWN Heart Outcomes Prevention Evaluation Study InvestigatorsG Dagenais
Mar 16, 2000·The Journal of Physiology·Y H ZhangY E Earm
Apr 1, 2000·Science·R G WalkerC S Zuker

❮ Previous
Next ❯

Citations

Jul 25, 2003·Journal of Molecular and Cellular Cardiology·Hiroshi HasegawaIssei Komuro
Oct 24, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jenni HuuskoSeppo Ylä-Herttuala
Jul 16, 2011·The Journal of Biological Chemistry·Babak RazaniClay F Semenkovich
May 13, 2003·Tissue Engineering·David C LatimerKevin Kit Parker
Apr 13, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Xin WuMariappan Muthuchamy
Mar 1, 2012·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihito KamedaHiroyuki Takano
Jan 26, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hiroshi HasegawaIssei Komuro
Aug 5, 2011·Canadian Journal of Physiology and Pharmacology·Elina KoivistoHeikki Ruskoaho
Jun 28, 2008·Current Opinion in Cell Biology·Martin A Schwartz, Douglas W DeSimone
Mar 28, 2007·Heart Failure Clinics·Giulio Selvetella, Giuseppe Lembo
Oct 21, 2003·The Journal of Physiology·Pasi TaviHeikki Ruskoaho
Jun 18, 2004·Annals of the New York Academy of Sciences·Jan LammerdingRichard T Lee
Jun 11, 2004·American Journal of Physiology. Cell Physiology·Hayden HuangRichard T Lee
Sep 24, 2004·Physiological Reviews·Popi Syntichaki, Nektarios Tavernarakis
Jan 4, 2003·Hypertension·Jarkko PiuholaHeikki Ruskoaho
Sep 7, 2002·Circulation Research·István SzokodiHeikki Ruskoaho
Nov 16, 2002·Circulation Research·Mark A SussmanThomas K Borg
May 6, 2019·International Journal of Molecular Sciences·Simona GalloTiziana Crepaldi
Jan 23, 2020·Heart Failure Reviews·Wolfgang KruegerMaciej Henneberg
Jun 6, 2003·Endocrine Reviews·John D BaxterPaul Webb
Jul 17, 2020·Frontiers in Cell and Developmental Biology·Roberto GaetaniElisa Messina
Mar 31, 2017·Science Translational Medicine·Teresa Kennedy-Lydon, Nadia Rosenthal
Oct 31, 2018·Frontiers in Physiology·Daniel M Johnson, Gudrun Antoons
Mar 1, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jarkko PiuholaHeikki Ruskoaho

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.