Cardiac Microvascular Dysfunction in Women Living With HIV Is Associated With Cytomegalovirus Immunoglobulin G

Open Forum Infectious Diseases
Andreas KnudsenAndreas Kjaer

Abstract

People living with HIV (PLWH) appear to be at increased risk of cardiovascular disease (CVD), and this is possibly more pronounced in women living with HIV (WLWH). In the general population, men are more likely to develop obstructive coronary artery disease (CAD), and women often present with a nonobstructive pattern with cardiac microvascular dysfunction. We investigated cardiac microvascular function in men and women living with HIV and tested for association with cytomegalovirus (CMV) immunoglobulin G (IgG), as this has been associated with CVD in PLWH. In a cross-sectional study, 94 PLWH on antiretroviral therapy were scanned with 82Rb positron emission tomography/computed tomography at rest and during adenosine-induced stress, which enables the quantification of the myocardial flow reserve (MFR). CMV IgG was measured in plasma. WLWH had significantly lower MFR compared with men living with HIV (MLWH; P = .003), and >45% of the women had an MFR indicative of cardiac microvascular dysfunction, whereas this was only true for 24% of men (P = .03). CMV IgG concentrations were inversely associated with MFR among WLWH but not MLWH (P = .05 for interaction). In this first study comparing MFR in women and men living with HIV, we fo...Continue Reading

References

Jan 1, 1991·American Heart Journal·K M AndersonW B Kannel
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Sep 17, 1983·Lancet·J L MelnickM E DeBakey
Aug 6, 2003·Circulation·Cairistine Grahame-ClarkePatrick Vallance
Sep 5, 2006·Journal of the American College of Cardiology·Keiichiro YoshinagaRob S B Beanlands
Jul 10, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Mireille LortieRobert A DeKemp
Apr 20, 2010·AIDS·Sylvie LangUNKNOWN French Hospital Database on HIV-ANRS CO4
Apr 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kenji FukushimaFrank M Bengel
Oct 19, 2011·Circulation·Venkatesh L MurthyMarcelo F Di Carli
Apr 12, 2012·The Journal of Infectious Diseases·Allison E Aiello, Amanda M Simanek
Apr 12, 2012·The Journal of Infectious Diseases·Christina M ParrinelloRobert C Kaplan
May 18, 2012·The Journal of Infectious Diseases·Priscilla Y HsuePeter W Hunt
Mar 6, 2013·JAMA Internal Medicine·Matthew S FreibergAmy C Justice
Sep 18, 2013·The Journal of Infectious Diseases·Kathleen V FitchSteven K Grinspoon
May 3, 2014·Circulation·Venkatesh L MurthyMarcelo F Di Carli
Oct 18, 2014·Journal of the American Heart Association·Julie A WomackMatthew S Freiberg
Nov 28, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Venkatesh L MurthyMarcelo F Di Carli
Mar 10, 2015·The Journal of Infectious Diseases·Sara GianellaDavey M Smith
Apr 24, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David B HannaLawrence A Kingsley
Oct 27, 2015·Journal of the American College of Cardiology·Carl J PepineUNKNOWN ACC CVD in Women Committee
Feb 18, 2016·BMC Infectious Diseases·Kristina ThorsteinssonAnne-Mette Lebech
Apr 9, 2016·JACC. Cardiovascular Imaging·Monica B PatelK Lance Gould
Aug 24, 2017·Current Opinion in HIV and AIDS·Lauren StoneMarkella V Zanni
Mar 31, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Borek FoldynaMarkella V Zanni

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Citations

Jul 17, 2019·Current Treatment Options in Cardiovascular Medicine·Rebecca A AbelmanMarkella V Zanni
Dec 20, 2019·Journal of the American Heart Association·Leah RethySanjiv J Shah
Sep 5, 2019·Current HIV/AIDS Reports·Mabel ToribioMarkella V Zanni

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