PMID: 16628279Apr 22, 2006Paper

Cardiac morphology and performance alterations and analysis of determinant factors of left ventricular hypertrophy in 40 patients with acromegaly

Arquivos brasileiros de endocrinologia e metabologia
Alessandra Ferri CasiniM R Gadelha

Abstract

Acromegaly has a high mortality rate due mainly to cardiovascular complications. The aim was to evaluate the determinant factors of left ventricular hypertrophy (LVH) and cardiac alterations in 40 acromegalic patients submitted to clinical-laboratorial studies and echocardiogram. The variables analyzed were age, sex, disease duration, arterial hypertension (AH), impaired glucose tolerance/DM, previous treatment with octreotide, GH and %IGF-I. Univaried analysis showed that patients with LVH were older (p= 0.031), had higher prevalence of AH (p= 0.009) and higher %IGF-I (p= 0.002), than those without LVH. Multivaried analysis showed AH and %IGF-I as determinants of LVH (p= 0.035 and p= 0.016). After dichotomizing of %IGF-I, a score was created and the frequency of LVH was 9%, 65%, 92% x 0, 1, 2; p< 0.0001. Prevalence of aortic ectasia was higher and valvar disease was smaller than reported in the literature. We conclude that AH and %IGF-I were determinants of LVH.

References

Jan 1, 1992·European Heart Journal·G KahalyJ Meyer
Dec 15, 1990·Annals of Internal Medicine·P ChansonJ Lubetzki
Oct 1, 1994·Endocrine Reviews·L SaccàS Fazio
Jul 1, 1994·Clinical Endocrinology·C RajasooryaH K Ibbertson
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·A ColaoG Lombardi
Mar 23, 1999·Circulation·A FrustaciA Maseri
Jan 14, 2000·The Journal of Clinical Endocrinology and Metabolism·S FazioL Saccà
Mar 7, 2000·Journal of Hypertension·M CiullaF Magrini
Feb 24, 2001·Clinical Endocrinology·A ColaoG Lombardi
Sep 5, 2001·Clinical Endocrinology·B L HerrmannK Mann
Jun 1, 2002·American Heart Journal·Caio B ViannaJose A F Ramires
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Annamaria ColaoGaetano Lombardi
Dec 28, 2002·Pituitary·M BondanelliE C degli Uberti
Jul 5, 2003·The Journal of Clinical Endocrinology and Metabolism·Annamaria ColaoGaetano Lombardi
Jan 13, 2004·The Journal of Clinical Endocrinology and Metabolism·Alberto M PereiraJeroen J Bax
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ian M HoldawayGreg D Gamble
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Nienke R BiermaszFerdinand Roelfsema
Aug 7, 2004·European Journal of Endocrinology·M M CiullaM Arosio
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Hélène BihanPhilippe Chanson

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Citations

May 26, 2018·Cardiology in Review·Michael D GoldbergWilliam H Frishman
Apr 28, 2011·Clinical Endocrinology·Alessandra Ferri CasiniMônica Roberto Gadelha
Dec 8, 2011·Arquivos brasileiros de endocrinologia e metabologia·Daniela FedrizziMauro Antônio Czepielewski
May 20, 2015·Endocrine·Cintia Marques Dos Santos SilvaM R Gadelha
Nov 14, 2013·Multidisciplinary Respiratory Medicine·Gustavo Bittencourt CamiloAgnaldo José Lopes
Oct 3, 2015·The Journal of Clinical Endocrinology and Metabolism·Cintia Marques Dos Santos SilvaMônica R Gadelha
Apr 20, 2021·Frontiers in Oncology·Han YangJianwei Li

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