Cardiac muscarinic receptor function in rats with cirrhotic cardiomyopathy

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
D N JaueS S Lee

Abstract

The pathogenesis of cirrhotic cardiomyopathy remains unclear. Because ventricular contractility is dependent on the interplay of stimulatory beta-adrenergic and inhibitory muscarinic receptors, we aimed to examine a possible role of muscarinic M2 receptor overactivity in a rat model of cirrhotic cardiomyopathy. Cirrhosis was induced by bile duct ligation (BDL), while controls underwent sham operations. Contractile responses to the muscarinic agonist carbachol were measured in situ in the autonomic-denervated pithed rat and in vitro in isolated ventricular papillary muscles. Ventricular sarcolemmal plasma membranes were isolated by sucrose density gradients, and muscarinic receptor characteristics were studied using 1-[N-methyl-3H]scopolamine (NMS). Membrane adenylyl cyclase activity was tested by a protein binding assay. Maximum first time derivative of peak ventricular systolic pressure (+dP/dt) for sham-operated and cirrhotic rats at baseline was 3,599 +/- 296 versus 1,226 +/- 63 mm Hg/sec (P < .01). Maximum first time derivative of ventricular diastolic relaxation (-dP/dt) for sham and cirrhotic rats at basal levels was -3,040 +/- 235 versus -864 +/- 59 (P < .01). The +dP/dt(max), and -dP/dt(max) responses to carbachol were ...Continue Reading

Citations

Jul 13, 2001·European Journal of Pharmacology·K NamiranianA R Dehpour
Apr 12, 2002·Journal of Hepatology·Jens H HenriksenSøren Møller
Mar 29, 2007·Orphanet Journal of Rare Diseases·Soon Koo BaikSamuel S Lee
Jul 10, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Waleed K Al-Hamoudi
Feb 13, 2009·Expert Review of Gastroenterology & Hepatology·Søren MøllerAleksander Krag
Dec 19, 2012·Journal of the Chinese Medical Association : JCMA·Ying-Ying Yang, Han-Chieh Lin
Sep 18, 2012·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mohammad M Abd ElaalGhada E Amr
Mar 27, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A MilaniP Pola
Jan 16, 2007·Best Practice & Research. Clinical Gastroenterology·Ralph F LeeSamuel S Lee
Mar 19, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Hongqun Liu, Samuel S Lee
Feb 2, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Eleni TheocharidouAndrew K Burroughs
May 16, 2015·Canadian Journal of Physiology and Pharmacology·Sattar OstadhadiAhmad-Reza Dehpour
May 14, 2010·Journal of Hepatology·Søren Møller, Jens H Henriksen
Aug 7, 2010·Journal of the American College of Cardiology·Enrico M ZardiArun J Sanyal
Mar 19, 2011·The Korean Journal of Hepatology·Moon Young KimSeung Hwan Lee
Feb 22, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Andrei VoiosuSøren Møller
Jul 27, 2017·Canadian Journal of Physiology and Pharmacology·Dagmar JarkovskaMagdalena Chottova Dvorakova
Nov 18, 2014·World Journal of Gastroenterology : WJG·Natig GassanovFikret Er
Jun 29, 1999·Journal of Gastroenterology and Hepatology·H Liu, S S Lee
Feb 21, 2006·World Journal of Gastroenterology : WJG·Soren Moller, Jens H Henriksen
Dec 21, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·H LiuS S Lee
Nov 12, 2015·World Journal of Gastroenterology : WJG·Luis Ruiz-del-Árbol, Regina Serradilla
May 25, 2016·World Journal of Gastroenterology : WJG·Seyed Soheil Saeedi SaraviAhmad Reza Dehpour
Jul 4, 2021·Current Cardiology Reports·Parul KakarChristine Gerula

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