Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family.

The Journal of Biological Chemistry
Y WangK R Chien

Abstract

p38 mitogen-activated protein (MAP) kinase activities were significantly increased in mouse hearts after chronic transverse aortic constriction, coincident with the onset of ventricular hypertrophy. Infection of cardiomyocytes with adenoviral vectors expressing upstream activators for the p38 kinases, activated mutants of MAP kinase kinase 3b(E) (MKK3bE) and MAP kinase kinase 6b(E) (MKK6bE), elicited characteristic hypertrophic responses, including an increase in cell size, enhanced sarcomeric organization, and elevated atrial natriuretic factor expression. Overexpression of the activated MKK3bE in cardiomyocytes also led to an increase in apoptosis. The hypertrophic response was enhanced by co-infection of an adenoviral vector expressing wild type p38 beta, and was suppressed by the p38 beta dominant negative mutant. In contrast, the MKK3bE-induced cell death was increased by co-infection of an adenovirus expressing wild type p38 alpha, and was suppressed by the dominant negative p38 alpha mutant. This provides the first evidence in any cell system for divergent physiological functions for different members of the p38 MAP kinase family. The direct involvement of p38 pathways in cardiac hypertrophy and apoptosis suggests a sign...Continue Reading

References

Dec 1, 1992·Current Opinion in Cell Biology·N G AhnE G Krebs
Sep 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·H A RockmanK R Chien
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K R ChienS Chien
Jun 1, 1991·Circulation·T X O'BrienK R Chien
Jan 1, 1989·Annual Review of Physiology·P C Simpson
Oct 1, 1980·The American Journal of Medicine·W Grossman
Nov 24, 1995·Science·Z XiaM E Greenberg
Mar 27, 1995·Annals of the New York Academy of Sciences·G LemboK R Chien
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·H A RockmanK R Chien
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J Blenis
Jan 1, 1993·Annual Review of Physiology·K R ChienS M Evans
Feb 9, 1996·The Journal of Biological Chemistry·J HanR J Ulevitch
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y WangG M Edelman
Jun 1, 1996·Circulation Research·T ForceJ M Kyriakis
Nov 12, 1996·Biochemical and Biophysical Research Communications·Z LiJ Han
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·K R GottshallK R Chien
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·C TournierR J Davis
Aug 1, 1997·Circulation Research·W R MacLellan, M D Schneider
Aug 8, 1997·The Journal of Biological Chemistry·T YinJ Whelan
Aug 15, 1997·The Journal of Biological Chemistry·J L KummerK A Heidenreich

❮ Previous
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Citations

Jan 6, 2000·The Anatomical Record·L ZhangJ He
Aug 14, 2001·Journal of Cellular Biochemistry·Y L GuoJ R Williamson
Jun 11, 2002·Journal of Molecular and Cellular Cardiology·Koichi Seta, Junichi Sadoshima
Jun 11, 2002·Journal of Molecular and Cellular Cardiology·Kou-ichi Tomaru KiMasahiko Kurabayashi
Dec 6, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Nobuhiro KanajiXiangde Liu
Dec 30, 2011·European Journal of Clinical Pharmacology·Sarawut KumphuneNipon Chattipakorn
Aug 11, 2012·Molecular and Cellular Biochemistry·Benoit BoivinBruce G Allen
Nov 9, 2010·Journal of Thrombosis and Thrombolysis·Reza Akbarzadeh NajarAkram Sadat Tabatabaei Panah
Jul 1, 2009·Cell Stress & Chaperones·Alessandra CorradettiAndrea L Tranquilli
Jun 7, 2005·The Journal of Surgical Research·Jeffrey M PitcherDaniel R Meldrum
Mar 20, 2004·Trends in Cardiovascular Medicine·Brian G Petrich, Yibin Wang
Dec 5, 2003·Journal of Molecular and Cellular Cardiology·Qiangrong Liang, Jeffery D Molkentin
Apr 6, 2000·The American Journal of Cardiology·A Clerk, P H Sugden
Feb 21, 2003·Biochemical and Biophysical Research Communications·Kinya OtsuMasatsugu Hori
Sep 23, 2003·Developmental Biology·Wei ShiDavid Warburton
May 20, 1999·European Journal of Pharmacology·N ParameswaranP Nambi
Jun 4, 1999·European Journal of Pharmacology·N ParameswaranP Nambi
Jun 6, 2003·Journal of Molecular and Cellular Cardiology·Angela Clerk
Nov 12, 2002·Mechanisms of Ageing and Development·Ching-Chyuan Hsieh, John Papaconstantinou
Nov 14, 2002·Progress in Biophysics and Molecular Biology·Florian Wernig, Qingbo Xu
Jun 4, 1999·Progress in Biophysics and Molecular Biology·M H Cobb
Apr 28, 1999·Lancet·T ForceR Hajjar
May 5, 2001·Pharmacology & Therapeutics·G A MichelottiD A Schwinn
Dec 4, 2001·Biology of the Cell·H Enslen, R J Davis
Oct 31, 2003·Experimental Hematology·Betty S PaceStuart D Critz
Feb 13, 2001·Free Radical Biology & Medicine·K Oh-HashiK Isobe
Feb 17, 2000·Cellular Signalling·K Ono, J Han
Jun 6, 2000·Trends in Biochemical Sciences·A R Nebreda, A Porras
Jan 11, 2001·Trends in Cardiovascular Medicine·J Han, J D Molkentin
May 7, 2003·Trends in Cardiovascular Medicine·Yeshao WenJerry Nadler
Feb 28, 2004·Trends in Cardiovascular Medicine·L New, J Han
Mar 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Shoji SakiyamaM Liu
Jan 19, 2000·Drug Discovery Today·I Wang, I Huang
Nov 19, 2003·Breast Cancer Research and Treatment·Melinda MerrellKatri S Selander
Sep 17, 2013·Nature Structural & Molecular Biology·Gian Felice DeNicolaMichael S Marber
Jun 11, 2002·British Journal of Pharmacology·László DénesPéter Csermely

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