Cardiac myxosarcoma with adrenal adenoma and pituitary hyperplasia resembling Carney complex in a dog

Veterinary Pathology
H A AdissuJ L Caswell

Abstract

A 9-year-old female Golden Retriever was presented with an acute onset of progressive respiratory distress. Echocardiography revealed a left atrial mass that limited blood flow from the pulmonary veins. The pathological evaluation revealed a left atrial ossifying myxosarcoma, bilateral adrenocortical adenomas, multifocal pituitary hyperplasia with expression of adrenocorticotrophic hormone, and multiple pituitary Rathke's cleft cysts. These pathologic findings are similar to those described in Carney complex, a familial human syndrome characterized by cardiac myxoma and extracardiac tumors associated with mutations in the protein kinase A regulator gene PRKAR1A. Mutations were not detected in PRKAR1A exons in the present case.

References

Jan 1, 1990·Journal of Veterinary Internal Medicine·J M BrightL A Blackford
Jan 1, 1985·The American Journal of Surgical Pathology·J A Carney
Dec 21, 1974·The Veterinary Record·P G Darke, L R Gordon
Dec 1, 1993·American Journal of Clinical Pathology·A P Burke, R Virmani
Apr 30, 1998·Journal of the South African Veterinary Association·O M BriggsN B Goldberg
Oct 31, 2000·Veterinary Pathology·M D Campbell, H B Gelberg
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·C A StratakisJ A Carney
Oct 14, 2003·Journal of Comparative Pathology·N MachidaY Yamane
Nov 26, 2003·The Journal of Small Animal Practice·R D FoaleM E Herrtage

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Citations

Oct 12, 2013·Journal of Veterinary Internal Medicine·M M J KoolJ A Mol
Jul 1, 2015·Molecular and Cellular Endocrinology·Sara Galac
Oct 1, 2015·Veterinary and Comparative Oncology·E TreggiariL Blackwood
Jun 24, 2016·Acta Veterinaria Scandinavica·Maria Irene de NijsViktor Szatmári
Jul 25, 2018·Journal of the American Animal Hospital Association·Dana M DeSandre-RobinsonDavid M Lurie
Jun 30, 2019·BMC Veterinary Research·Yoshimi IwakiJayme Looper
Jan 29, 2021·The Journal of Veterinary Medical Science·Atsuhito Wada, Katsuyuki Nagata

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Methods Mentioned

BETA
PCR

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