Cardiac neural crest of the mouse embryo: axial level of origin, migratory pathway and cell autonomy of the splotch (Sp2H) mutant effect

Development
Wood Yee ChanAndrew J Copp

Abstract

A sub-population of the neural crest is known to play a crucial role in development of the cardiac outflow tract. Studies in avians have mapped the complete migratory pathways taken by 'cardiac' neural crest cells en route from the neural tube to the developing heart. A cardiac neural crest lineage is also known to exist in mammals, although detailed information on its axial level of origin and migratory pattern are lacking. We used focal cell labelling and orthotopic grafting, followed by whole embryo culture, to determine the spatio-temporal migratory pattern of cardiac neural crest in mouse embryos. Axial levels between the post-otic hindbrain and somite 4 contributed neural crest cells to the heart, with the neural tube opposite somite 2 being the most prolific source. Emigration of cardiac neural crest from the neural tube began at the 7-somite stage, with cells migrating in pathways dorsolateral to the somite, medial to the somite, and between somites. Subsequently, cardiac neural crest cells migrated through the peri-aortic mesenchyme, lateral to the pharynx, through pharyngeal arches 3, 4 and 6, and into the aortic sac. Colonisation of the outflow tract mesenchyme was detected at the 32-somite stage. Embryos homozygous ...Continue Reading

References

Apr 1, 1992·Cell and Tissue Research·Y Fukiishi, G M Morriss-Kay
Aug 1, 1990·Circulation·M L Kirby, K L Waldo
Jan 1, 1989·Anatomy and Embryology·T Franz
Aug 1, 1986·Developmental Biology·G C TuckerJ P Thiery
Aug 1, 1969·Australian Journal of Biological Sciences·D G Whittingham, R G Wales
Nov 23, 1995·The New England Journal of Medicine·K J RothmanA Milunsky
Aug 1, 1995·Circulation Research·M L Kirby, K L Waldo
Dec 1, 1994·Current Opinion in Pediatrics·D A Driscoll
Aug 1, 1993·Genomics·M GouldingP Gruss
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D J EpsteinP Gros
May 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A L Means, L J Gudas
Jul 3, 1998·The Journal of Clinical Investigation·H YanagisawaM Yanagisawa
Oct 9, 1998·Anatomy and Embryology·M E VerberneR E Poelmann
Dec 16, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M V ReedyC A Erickson
Dec 1, 1999·Trends in Cardiovascular Medicine·C W LoM L Kirby
Dec 22, 1999·Current Opinion in Cell Biology·M García-Castro, M Bronner-Fraser
Mar 21, 2000·Genesis : the Journal of Genetics and Development·J LiJ A Epstein
Jul 25, 2000·Mechanisms of Development·R Perris, D Perissinotto
Nov 7, 2000·Current Opinion in Cell Biology·J H ChristiansenD G Wilkinson
May 29, 2001·American Journal of Medical Genetics·K L Maschhoff, H S Baldwin
Nov 1, 1996·Trends in Cardiovascular Medicine·J A Epstein

❮ Previous
Next ❯

Citations

Dec 24, 2004·Pediatric Surgery International·S Gonzalez-ReyesJa Tovar
Sep 1, 2005·Cell and Tissue Research·R B AndersonH M Young
Apr 1, 2009·Apoptosis : an International Journal on Programmed Cell Death·James H ChappellMary R Loeken
Sep 18, 2012·Nature Structural & Molecular Biology·Aydan Bulut-KarsliogluThomas Jenuwein
May 2, 2006·Stem Cells and Development·Chris PierretMark D Kirk
Feb 7, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Karl J L FernandesFreda D Miller
May 1, 2008·Pigment Cell & Melanoma Research·Flavia Carneiro Brito, Lidia Kos
May 18, 2007·Annual Review of Cell and Developmental Biology·Margaret Buckingham, Frédéric Relaix
Aug 6, 2008·BMC Developmental Biology·Kwok-Kuen CheungWood Yee Chan
Feb 22, 2012·Journal of Visualized Experiments : JoVE·Shannon L Griswold, Peter Y Lwigale
Mar 30, 2010·Autonomic Neuroscience : Basic & Clinical·Heather M YoungColin R Anderson
Apr 26, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sarah C MorganMary R Loeken
Jan 22, 2011·Genesis : the Journal of Genetics and Development·Brian L NelmsPatricia A Labosky
Oct 22, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bryan R Kuo, Carol A Erickson
Nov 5, 2010·Developmental Biology·Akouavi M EzinScott E Fraser
Apr 18, 2008·Developmental Biology·James E N Minchin, Simon M Hughes
Feb 5, 2008·Developmental Biology·Hong-Ming ZhouSimon J Conway
Jul 25, 2006·Developmental Biology·Mariko SatoH Joseph Yost
Oct 22, 2010·Cell Adhesion & Migration·Bryan R Kuo, Carol A Erickson
Jan 12, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kenyi Saito-Diaz, Nadja Zeltner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.