PMID: 9185337May 1, 1997Paper

Cardiac nuclear encoded cytochrome c oxidase subunits are decreased with copper restriction but not iron restriction: gene expression, protein synthesis and heat shock protein aspects

Comparative Biochemistry and Physiology. Part A, Physiology
D M MedeirosT Samelman

Abstract

Hearts from rats fed a copper-deficient (Cu-) diet have decreased levels of nuclear-encoded peptides of cytochrome c oxidase (CCO). Studies were conducted to determine whether iron deficiency would lead to a similar finding, whether mRNA transcripts and the chaperonin heat shock proteins (HSP) 60 and 70 from hearts of Cu- rats were decreased as compared with copper-adequate controls and whether synthesis of mitochondrial and nuclear encoded peptides differed as affected by diet copper. In study 1, weanling rats were assigned to one of three groups (n = 6 in each group): (1) control copper and iron adequate fed rats; (2) Cu- rats and (3) iron-deficient (Fe-) rats. Western blotting of nonmyofibrillar cardiac proteins revealed that the nuclear encoded peptides of CCO from the Cu- rats were markedly decreased as compared with control and Fe- rats. Mitochondrial encoded subunits did not appear to differ by treatment groups. Iron-deficient rats had similar nuclear encoded peptide levels as those of controls. In study 2, mRNA transcripts from Cu- (n = 4) and control copper adequate (n = 4) rats did not appear to differ for subunits II and IV, which correspond to mitochondrial and nuclear encoded subunits, respectively. In study 3, lev...Continue Reading

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Citations

Jan 5, 2000·BioFactors·J T Saari, D A Schuschke
Aug 2, 2013·Biological Trace Element Research·Ayşegül BayırFikret Akyürek
Aug 26, 2014·Journal of Biotechnology·Sohye KangPavel V Bondarenko
Feb 23, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Margaret BroderiusJoseph R Prohaska
Aug 25, 2009·Nutrition Research·Margaret A Broderius, Joseph R Prohaska
Jul 9, 2013·Biochemical and Biophysical Research Communications·Rodrigo I BustosAlvaro A Elorza
Oct 22, 2008·Methods : a Companion to Methods in Enzymology·Denis M Medeiros
Oct 18, 2001·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·G MielcarzD L Stone
Feb 1, 2006·Experimental Biology and Medicine·W Thomas Johnson, Holly M Brown-Borg
Aug 8, 2019·Hepatology Communications·Lei YuJason Burkhead
Jul 23, 2016·Biological Trace Element Research·Denis M Medeiros
Sep 11, 2021·Frontiers in Molecular Biosciences·Lina M RuizAlvaro A Elorza
Jul 8, 2008·The Journal of Nutritional Biochemistry·W Thomas Johnson, Luann K Johnson
Oct 11, 2005·Journal of Proteome Research·Alessandra ToscoLiberato Marzullo

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