Cardiac Optogenetics: 2018

JACC. Clinical Electrophysiology
Patrick M BoyleNatalia A Trayanova

Abstract

Cardiac optogenetics is an emergent research area involving the delivery of light-sensitive proteins (opsins) to excitable heart tissue to enable optical modulation of cardiac electrical function. Optogenetic stimulation has many noteworthy advantages over conventional electrical methods, including selective electrophysiological modulation in specifically targeted cell subpopulations, high-resolution spatiotemporal control via patterned illumination, and use of different opsins to elicit inward or outward transmembrane current. This review summarizes developments achieved since the inception of cardiac optogenetics research, which has spanned nearly a decade. The authors first provide an overview of recent methodological advances in opsin engineering, light sensitization of cardiac tissue, strategies for illuminating the heart, and frameworks for simulating optogenetics in realistic computational models of patient hearts. They then review recent cardiac optogenetics applications, including: 1) all-optical, high-throughput, contactless assays for quantification of electrophysiological properties; 2) optogenetic perturbation of cardiac tissue to unveil mechanistic insights on the initiation, perpetuation, and termination of arrhy...Continue Reading

References

Jun 29, 2002·Science·Georg NagelPeter Hegemann
Nov 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georg NagelErnst Bamberg
Jul 27, 2005·Biochemical Society Transactions·G NagelE Bamberg
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Nov 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiang LiStefan Herlitze
Oct 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karl DeisserothMark J Schnitzer
Oct 1, 2010·Nature Methods·Tobias BruegmannPhilipp Sasse
Nov 13, 2010·Science·Aristides B ArrenbergJan Huisken
Aug 11, 2011·Circulation. Arrhythmia and Electrophysiology·Zhiheng JiaEmilia Entcheva
Sep 29, 2011·Biophysical Journal·Oscar J AbilezEllen Kuhl
Mar 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Emilia Entcheva
Aug 29, 2013·Nature Communications·Patrick M BoyleNatalia A Trayanova
Sep 27, 2013·PLoS Computational Biology·John C WilliamsEmilia Entcheva
Aug 2, 2014·Cardiovascular Research·Brian O BingenAntoine A F de Vries
Aug 20, 2014·Scientific Reports·Sarah A ParkDavid T Yue
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alexej DawydowRobert J Kittel
Nov 2, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Thomas V KarathanosNatalia A Trayanova
Dec 3, 2014·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Parikshit S SharmaPugazhendhi Vijayaraman
Jan 15, 2015·Cardiovascular Research·Christoph C VogtPhilipp Sasse
May 24, 2015·Computers in Biology and Medicine·Patrick M BoyleNatalia A Trayanova
Jun 23, 2015·Nature Biotechnology·Udi Nussinovitch, Lior Gepstein
Jul 25, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tania ZagliaMarco Mongillo
Nov 17, 2015·Scientific Reports·Jinzhu YuEmilia Entcheva
Apr 9, 2016·Nature Photonics·Rebecca A B BurtonGil Bub
Apr 26, 2016·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Sohail ZahidNatalia A Trayanova
May 11, 2016·Nature Communications·Aleksandra KlimasEmilia Entcheva
May 18, 2016·Journal of Pharmacological and Toxicological Methods·Graham T DempseyJoel M Kralj
Jun 11, 2016·Journal of Pharmacological and Toxicological Methods·Thomas ColatskyNorman Stockbridge
Sep 13, 2016·The Journal of Clinical Investigation·Tobias BruegmannPhilipp Sasse
Sep 16, 2016·Scientific Reports·Elena G GovorunovaJohn L Spudich
Oct 18, 2016·Scientific Reports·Claudia CrociniLeonardo Sacconi
Dec 9, 2016·Proceedings of the National Academy of Sciences of the United States of America·T Alexander QuinnPeter Kohl
Jan 7, 2017·Circulation Research·Roger J Hajjar, Kiyotake Ishikawa
Jan 9, 2017·Trends in Cardiovascular Medicine·Barry Greenberg

❮ Previous
Next ❯

Citations

Jun 6, 2019·Methods and Protocols·Tania ZagliaMarco Mongillo
Sep 12, 2019·BioFactors·Hoda Keshmiri NeghabMichael Grusch
Feb 8, 2020·Cardiovascular Research·Patrick M Boyle, Natalia A Trayanova
Oct 2, 2019·Frontiers in Physiology·Emily A FerencziChristopher L-H Huang
Feb 18, 2020·Frontiers in Bioengineering and Biotechnology·Jyotsna JoshiWuqiang Zhu
Jun 9, 2020·ELife·Rupamanjari MajumderDaniël A Pijnappels
Mar 1, 2019·Science Translational Medicine·Emile C A NynsDaniël A Pijnappels
May 16, 2020·Frontiers in Physiology·Christopher L-H HuangMing Lei
Dec 20, 2020·Nature Reviews. Cardiology·Emilia Entcheva, Matthew W Kay
Feb 12, 2021·Biosensors & Bioelectronics·Ting-Wei WangShien-Fong Lin
Nov 17, 2020·BioMed Research International·Mariana FloriaDaniela Maria Tanase
May 30, 2021·Current Cardiology Reports·Xiao-Dong ZhangNipavan Chiamvimonvat
Jul 1, 2020·Communications Biology·Jing MenChao Zhou
Aug 10, 2021·Frontiers in Systems Neuroscience·Sven StorchMatilde Balbi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.