Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells

Development
Vesa KaartinenJonathan A Epstein

Abstract

Cardiac neural crest cells are multipotent migratory cells that contribute to the formation of the cardiac outflow tract and pharyngeal arch arteries. Neural crest-related developmental defects account for a large proportion of congenital heart disorders. Recently, the genetic bases for some of these disorders have been elucidated, and signaling pathways required for induction, migration and differentiation of cardiac neural crest have emerged. Bone morphogenetic proteins comprise a family of secreted ligands implicated in numerous aspects of organogenesis, including heart and neural crest development. However, it has remained generally unclear whether BMP ligands act directly on neural crest or cardiac myocytes during cardiac morphogenesis, or function indirectly by activating other cell types. Studies on BMP receptor signaling during organogenesis have been hampered by the fact that receptor knockouts often lead to early embryonic lethality. We have used a Cre/loxP system for neural crest-specific deletion of the type I receptor, ALK2, in mouse embryos. Mutant mice display cardiovascular defects, including persistent truncus arteriosus, and abnormal maturation of the aortic arch reminiscent of common forms of human congenital...Continue Reading

References

Dec 1, 1995·Nature Genetics·G ProetzelT Doetschman
Aug 1, 1995·Circulation Research·M L Kirby, K L Waldo
Jan 5, 1995·Biochemical and Biophysical Research Communications·Y MishinaR R Behringer
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K TsuchidaW W Vale
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A B KulkarniS Karlsson
Mar 1, 1996·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K L WaldoM L Kirby
Sep 1, 1997·Developmental Biology·A SuzukiA Hemmati-Brivanlou
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y ChenW Vale
Apr 29, 1998·Annual Review of Physiology·T L CreazzoM L Kirby
Sep 25, 1998·The Journal of Biological Chemistry·M Macías-SilvaJ L Wrana
Oct 6, 1998·Annual Review of Biochemistry·J Massagué
Jun 8, 1999·The Journal of Clinical Investigation·K WaldoM L Kirby
Sep 10, 1999·Developmental Biology·Y MishinaR R Behringer
Dec 28, 1999·Annual Review of Cell and Developmental Biology·C LaBonne, M Bronner-Fraser
Jul 6, 2000·Trends in Cardiovascular Medicine·M FarrellM L Kirby
Sep 27, 2000·Human Molecular Genetics·P J Scambler
Mar 10, 2001·Nature Genetics·L A Jerome, V E Papaioannou
Mar 17, 2001·Nature Reviews. Molecular Cell Biology·J Massagué
May 22, 2001·Molecular Biology of the Cell·L BlavierV Kaartinen
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A LoonstraJ Jonkers
Oct 5, 2001·Trends in Genetics : TIG·J A Epstein
Nov 1, 2001·Annual Review of Cell and Developmental Biology·J Capdevila, J C Izpisúa Belmonte
Dec 18, 2001·Genesis : the Journal of Genetics and Development·V Kaartinen, A Nagy
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Vinciane GaussinMichael D Schneider
Apr 5, 2002·Trends in Genetics : TIG·Robert G Kelly, Margaret E Buckingham
Jun 4, 2002·Nature Reviews. Genetics·Anne K Knecht, Marianne Bronner-Fraser
Jul 24, 2002·Circulation·T Mesud YelbuzMargaret L Kirby
Sep 28, 2002·Mechanisms of Development·Natascia TisoFrancesco Argenton
Oct 9, 2002·Nature Genetics·Soazik P JaminRichard R Behringer

❮ Previous
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Citations

May 2, 2012·Cellular and Molecular Life Sciences : CMLS·Timothy J Stuhlmiller, Martín I García-Castro
Dec 30, 2009·Pediatric Cardiology·Stacey RentschlerJonathan A Epstein
Apr 9, 2008·Basic Research in Cardiology·Irene C JoziassePeter A Doevendans
Jan 29, 2008·Biological Trace Element Research·Veronica LopezLouise Lanoue
Mar 17, 2009·Anatomical Science International·Toshiyuki YamagishiHiroaki Nakamura
May 6, 2005·Cytokine & Growth Factor Reviews·Satoshi Kishigami, Yuji Mishina
Aug 13, 2010·Nature Reviews. Rheumatology·Eileen M Shore, Frederick S Kaplan
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wei LiChing-Pin Chang
May 14, 2010·The Journal of Biological Chemistry·Gin-Ah SongHyun-Mo Ryoo
May 2, 2006·Stem Cells and Development·Chris PierretMark D Kirk
Jun 4, 2013·Interactive Cardiovascular and Thoracic Surgery·Nada AbdulkareemMarjan Jahangiri
Jul 11, 2007·TheScientificWorldJournal·Paige SniderSimon J Conway
Dec 2, 2011·Journal of Biomedicine & Biotechnology·Gang WuDezhi Mu
Oct 25, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Yucheng YaoKristina I Boström
Jul 16, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhaokang ChengJoan M Taylor
Feb 3, 2007·The Journal of Clinical Investigation·Frances A HighJonathan A Epstein
Jul 10, 2009·The Journal of Clinical Investigation·Ainara Vallejo-IllarramendiLouis F Reichardt
Jan 27, 2011·The Journal of Clinical Investigation·Stacey RentschlerJonathan A Epstein
Jan 29, 2013·Cilia·Marc August WillaredtKerry L Tucker
May 23, 2007·Pediatric Research·J Robert SchleiffarthAnna Petryk
Aug 23, 2012·Development·Chien-Jung LinChing-Pin Chang
May 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Di AiJames F Martin
Jun 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jian LiMichael S Parmacek
Jun 5, 2012·Differentiation; Research in Biological Diversity·Boudewijn P T KruithofMarie-José Goumans
May 19, 2012·Differentiation; Research in Biological Diversity·Anna Keyte, Mary Redmond Hutson
Nov 7, 2009·Cytokine & Growth Factor Reviews·Vicki Rosen
Jan 17, 2007·Seminars in Cell & Developmental Biology·Mary R Hutson, Margaret L Kirby
Dec 21, 2006·Seminars in Cell & Developmental Biology·Huansheng Xu, Antonio Baldini
Jul 17, 2009·American Journal of Medical Genetics. Part a·Shankar BaskarPreethi Muralidhar Kulkarni
May 22, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ann Marie Scholl, Margaret L Kirby
Apr 25, 2009·Genesis : the Journal of Genetics and Development·Takashi UchimuraYuji Mishina
Oct 17, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·David J McCulleyBrian L Black
Jun 11, 2008·Genesis : the Journal of Genetics and Development·Jieun Kim, Vesa Kaartinen
Apr 11, 2006·Genesis : the Journal of Genetics and Development·Tomokazu FukudaYuji Mishina
Nov 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoshihiro KomatsuYuji Mishina

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