Cardiac output and oxygen delivery during exercise in sickle cell anemia

The American Review of Respiratory Disease
P PianosiA L Coates

Abstract

Desaturation in patients with sickle cell anemia (SCA) can lead to intravascular sickling and vascular occlusion. The increased metabolic demands of exercise tend to increase oxygen extraction, giving rise to a fall in saturation in the capillary bed that may predispose to sickling. This could be minimized with an increase in cardiac output. The aims of this study were to assess the role of increased stroke volume (SV) in augmenting cardiac output (Q) and to estimate the role of enlarged arteriovenous O2 content difference in maintaining O2 transport in children with SCA. A group of 30 children with SCA (Hb 65 to 133 g/L) and 16 healthy controls of the same racial group and of similar height and weight performed incremental and steady-state exercise at 50% Wmax. Cardiac output (Q) was measured by the indirect (CO2) Fick method during steady state. The slope of delta HR/delta VO2 during incremental exercise was higher in SCA subjects compared with controls (4.01 +/- 1.73 versus 2.80 +/- 0.61 bpm per ml/min/kg VO2, p = 0.001). Q for VO2 was abnormally high in patients, particularly older ones with lower Hb levels. HR (% predicted) was higher in patients than in controls (106 +/- 11 versus 92 +/- 8% predicted, p less than 0.0001),...Continue Reading

References

Jan 1, 1988·The American Review of Respiratory Disease·J HortopA L Coates
Feb 1, 1988·The American Journal of Cardiology·I C BalfourC Jones
Nov 1, 1954·Circulation·L LEIGHTH K HELLEMS

Citations

Jul 12, 2002·Annals of Neurology·Mara PrenglerRobert J Adams
Jun 1, 1993·Archives of Disease in Childhood·P PianosiA L Coates
Aug 28, 2012·Chest·Rifat A ChaudrySuzanne Crowley
Jan 27, 2017·Children·Paolo T PianosiHan C G Kemper
Apr 6, 2017·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Roberta Pulcheri Ramos
Dec 25, 2015·British Journal of Sports Medicine·Cyril MartinPhilippe Connes
Apr 6, 2018·Journal of Pediatric Hematology/oncology·Kelly A DoughertyVirginia A Stallings
Mar 20, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Raimund Hirschberg

Related Concepts

Anemia, Sickle Cell
Arteries
Cardiac Output
Electrocardiographic Recorders
Pulse Rate
Eryhem
Dioxygen
Oxygen Consumption
Rest
Veins

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.