Cardiac oxidative stress and remodeling following infarction: role of NADPH oxidase.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
Wenyuan ZhaoYao Sun

Abstract

There is growing recognition that oxidative stress plays a role in the pathogeneses of myocardial repair/remodeling following myocardial infarction (MI). Nicotinamide adenine denucleotide phosphate (NADPH) oxidase is a major source for cardiac reactive oxygen species production. Herein, we studied the importance of NADPH oxidase in development of cardiac oxidative stress and its induced molecular and cellular changes related to myocardial repair/remodeling. MI was created by coronary artery ligation in C57/BL (wild type) and NADPH oxidase (gp91(phox)) knockout mice. Cardiac oxidative stress, inflammatory/fibrogenic responses, apoptosis, and hypertrophy were detected by in situ hybridization, immunohistochemistry, terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling (TUNEL), picrosirius red staining, and image analysis, respectively, at different stages post MI. In wild-type mice with MI, and compared to sham-operated animals, we observed significantly increased gp91(phox) and 3-nitrotyrosine, a marker of oxidative stress, in the infarcted myocardium; accumulated macrophages and myofibroblasts at the infarct site; abundant apoptotic myocytes primarily at border zones on Day 3; and numerous apoptotic inflammatory/m...Continue Reading

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Citations

Oct 24, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Pamela W M KleikersH H H W Schmidt
Jul 12, 2011·Physiological Reviews·Jeffrey R EricksonMark E Anderson
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Maqsood M ElahiBashir M Matata
Oct 4, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Tomomi HasegawaDavid J Pinsky
Jul 20, 2011·Journal of Molecular and Cellular Cardiology·Wenyuan ZhaoYao Sun
Jan 22, 2011·Journal of Cellular and Molecular Medicine·K T MoeP Wong
Nov 28, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Byeong Hyeok YeChi Dae Kim
Aug 5, 2015·PloS One·Wenyuan ZhaoYao Sun
Apr 30, 2017·Pflügers Archiv : European journal of physiology·Li-Ping WangXiu-Hong Yang
Jan 9, 2017·Cardiovascular Drugs and Therapy·Russell G Rogers, Jeffrey S Otis
Nov 18, 2021·Journal of Cellular and Molecular Medicine·Qing WangDan-Ni Ren

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