Cardiac pathologies in female carriers of Duchenne muscular dystrophy assessed by cardiovascular magnetic resonance imaging

European Radiology
Juliane SchelhornThomas Schlosser

Abstract

Duchenne muscular dystrophy (DMD) is the most common and severe dystrophinopathy. DMD carriers rarely present with clinical symptoms, but may suffer from cardiac involvement. Because echocardiographic findings are inconsistent and cardiac magnetic resonance imaging (CMRI) data are limited, this study sought to investigate asymptomatic carriers for cardiac abnormalities using CMRI. Fifteen genetically confirmed DMD carriers (age, 32.3 ± 10.2 years) were prospectively examined on a 1.5T MR system. Cine, T2, and late-gadolinium-enhanced (LGE) images were acquired, and were evaluated in consensus by two experienced readers. Left ventricular (LV) parameters were analysed semiautomatically, normalized to BSA. Normalized LV end-diastolic volume was increased in 7% (73.7 ± 16.8 ml/m(2); range, 48-116 ml/m(2)) and normalized LV end-systolic volume in 20% (31.5 ± 13.3 ml/m(2); range, 15-74 ml/m(2)). EF was reduced in 33% (58.4 ± 7.6%; range, 37-69%) and normalized LV myocardial mass in 80% (40.5 ± 6.8 g/m(2); range, 31-55 g/m(2)). In 80%, regional myocardial thinning was detected in more than one segment. In 13% and 40%, apical-lateral accentuation of LV non-compaction was present. LGE was found in 60% (midmyocardial inferolateral accent...Continue Reading

References

Mar 1, 1992·International Journal of Cardiology·L I ComiV R Petretta
May 1, 1996·JAMA : the Journal of the American Medical Association·L PolitanoL I Comi
Feb 18, 2003·Cardiology·Josef Finsterer, Claudia Stöllberger
Jul 5, 2005·Journal of the American College of Cardiology·Steffen E PetersenStefan Neubauer
Jun 8, 2006·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·A M MaceiraD J Pennell
Nov 2, 2006·Cardiology·Josef FinstererHans Feichtinger
May 8, 2007·Journal of the American College of Cardiology·Marly Conceição SilvaCarlos Eduardo Rochitte
Aug 8, 2008·The International Journal of Cardiovascular Imaging·Michael D PuchalskiWilliam M Gottliebson
Aug 19, 2008·International Journal of Cardiology·Thomas WalcherJan Torzewski
Nov 6, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Dewi E ThomasNavroz D Masani
Jul 16, 2010·Neuromuscular Disorders : NMD·Sophie MavrogeniGeorge Dangas
Oct 12, 2010·International Journal of Cardiology·Josef FinstererPaul Wexberg
Feb 12, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Ali YilmazUdo Sechtem
Apr 14, 2012·Circulation. Cardiovascular Imaging·Nadine KawelDavid A Bluemke
Apr 21, 2012·Heart & Lung : the Journal of Critical Care·Claudia StöllbergerJosef Finsterer
May 18, 2012·International Journal of Cardiology·Josef FinstererChristoph Schukro
Jan 3, 2013·Heart, Lung & Circulation·Victoria E Cheng, David L Prior
May 2, 2013·Journal of Clinical Monitoring and Computing·Abdallah FayssoilDjillali Annane
Aug 7, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher J StatileKan N Hor
Dec 17, 2014·JACC. Cardiovascular Imaging·Sabiha GatiJohn B Chambers

❮ Previous
Next ❯

Citations

May 28, 2016·Journal of the American College of Cardiology·Forum Kamdar, Daniel J Garry
Apr 30, 2019·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Edyta BlaszczykJeanette Schulz-Menger
May 31, 2019·European Heart Journal·Samantha B RossChristopher Semsarian
Jul 29, 2021·Current Heart Failure Reports·Edyta BlaszczykJeanette Schulz-Menger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.