PMID: 8938854Nov 1, 1996Paper

Cardiac performance in conscious healthy dogs during dobutamine infusion

Research in Veterinary Science
K McEnteeM Henroteaux

Abstract

The aim of this study was to determine the cardiac performance of conscious healthy dogs during stimulation with dobutamine. Eight healthy unsedated beagle dogs were used. Cardiac output was measured by the thermodilution technique and blood pressures by extravascular pressure transducers. Dobutamine challenge at a dosage ranging from 27.5 to 50 micrograms kg-1 min-1 induced a significant rise in cardiac power index (CPI), cardiac index (CI), stroke index (SI) and heart rate (HR) and a significant decrease in pulmonary vascular resistance (PVR) and systemic vascular resistance (SVR). The highest CPI was 2.05 times greater than its basal resting value. The CI was primarily responsible for this increase in CPI. The SI and HR contributed approximately 55 per cent and 45 per cent respectively of the maximal increase in CI.

References

Dec 1, 1975·The American Journal of Cardiology·J E Hinds, E W Hawthorne
Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·J H CissikW A Pierson
Dec 1, 1993·Canadian Journal of Physiology and Pharmacology·H AmoryP M Lekeux
Sep 1, 1993·The American Journal of Cardiology·J P EichelbergerK Ouriel

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Citations

Dec 29, 2005·American Journal of Veterinary Research·Guillaume P ChanoitHervé P Lefebvre
Apr 20, 2010·Journal of Pharmacological and Toxicological Methods·Cristian T BadeaG Allan Johnson
Oct 24, 2006·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H GehlenP Stadler
Nov 10, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ken Grime, Stuart W Paine
Dec 1, 2000·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·K Mc EnteeM Henroteaux

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