Cardiac radiation dose distribution, cardiac events and mortality in early-stage lung cancer treated with stereotactic body radiation therapy (SBRT)

Journal of Thoracic Disease
Leonid B ReshkoElisabeth Weiss

Abstract

The impact of radiation dose to the heart in early-stage lung cancer patients treated with definitive stereotactic body radiation therapy (SBRT) is not well known. We, therefore, analyzed whether higher radiation dose to the heart would lead to an increase in cardiac toxicity and overall mortality. Seventy-four patients with 75 tumors treated definitively with SBRT for early-stage non-small cell lung cancer (NSCLC) and two cases of limited-stage small cell lung cancer (SCLC) with an average follow-up of 35 months (range, 1-130 months) were retrospectively analyzed. The whole heart and cardiac substructures including atria, ventricles, heart valves, atrioventricular (AV) node and four major coronary artery branches were contoured using commercial treatment planning software. For each structure, multiple dose-volume parameters were recorded. The relation between radiation doses to the heart, tumor location, and preexisting medical conditions with the development of cardiac events and mortality was assessed. Overall, there was large variability in dose to cardiac substructures: mean heart dose (MHD) averaged 1.90 Gy (range, 0.04-11.00 Gy) equivalent 2 Gy dose (EQD2) and average max dose to the left anterior descending artery (LAD)...Continue Reading

Citations

Feb 15, 2019·Journal of Computer Assisted Tomography·Xin LiNikhil H Ramaiya
Aug 15, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R JumeauV Ferchaud
Jan 23, 2021·Archives of Cardiovascular Diseases·Frédéric SacherUNKNOWN Working Group of Cardiac Pacing, Electrophysiology of the French Society of Cardiology
Mar 9, 2021·World Journal of Clinical Oncology·Mark FarrugiaHarish Malhotra
Feb 10, 2021·Practical Radiation Oncology·Pierre LoapYoulia Kirova
Nov 5, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P LoapY Kirova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Related Papers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Gaurav MarwahaGregory M M Videtic
© 2022 Meta ULC. All rights reserved