Cardiac release and kinetics of endothelin after uncomplicated percutaneous transluminal coronary angioplasty

The American Journal of Cardiology
D KrügerU Stierle

Abstract

This study was designed to assess the release kinetics of endothelin after percutaneous transluminal coronary angioplasty (PTCA) and to prove the coronary endothelium as the source of the endothelin release. Twenty-seven patients with single-vessel coronary artery disease underwent PTCA. Endothelin, troponin T, myoglobin, and creatine phosphokinase paired blood samples were withdrawn from the coronary sinus and a peripheral vein before the balloon maneuver and at 1, 5, 10, 30, 45 minute(s), and at 1, 2, 3, 6, 12, and 24 hour(s) after the last balloon maneuver. Myocardial ischemia was monitored by means of cardiac lactate metabolism and 12-lead electrocardiogram. Thirteen patients who underwent a diagnostic cardiac catheterization served as a control group. In the left coronary artery, PTCA (n = 19) endothelin concentrations increased from 4.1 pg/ml as a common mean baseline level before intervention to 13.9 +/- 2.6 pg/ml (mean +/- SD) in the coronary sinus and 7.9 +/- 2.2 pg/ml (mean +/- SD) in the peripheral vein at 1 minute after the intervention (p <0.001). The levels remained elevated for 3 hours with higher coronary sinus than peripheral venous concentrations due to persistent cardiac endothelin release. PTCA of the right ...Continue Reading

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Citations

Mar 17, 2010·Journal of Thrombosis and Thrombolysis·NourEddine ElMokhtariDietmar Krüger
Apr 27, 2000·The American Journal of Cardiology·T C WuM S Chang
Nov 7, 2003·The Annals of Thoracic Surgery·Walter J GomesEnio Buffolo
Jun 29, 2005·International Journal of Cardiology·Periklis A DavlourosAntonis S Manolis
Mar 1, 2002·Critical Care Nursing Quarterly·A D Angerio, D A Fink
Sep 6, 2000·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Y HojoK Shimada
Oct 17, 2003·Coronary Artery Disease·Arshia Noori, Samer Kabbani
Aug 16, 2005·Scandinavian Cardiovascular Journal : SCJ·Arnfinn IlebekkTorstein Lyberg

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