PMID: 8597885Nov 1, 1995Paper

Cardiac release of histamine after ventricular fibrillation and defibrillation during insertion of implantable cardioverter defibrillators (ICD)

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
G ValenJ Vaage

Abstract

Histamine has inotropic, chronotropic, arrhythmogenic, and vasoactive effects, and is released from the heart in ischaemia-reperfusion injury. The effect of ventricular fibrillation (VF) and defibrillation (DEF) on histamine release was investigated in 9 anaesthetized patients undergoing transvenous implantation of ICD. Concomitant arterial and coronary sinus (CS) blood samples were drawn before induction of VF (duration 20 seconds), immediately after, and 2 and 5 min after DEF (18-24 Joules). Basal arterial histamine was 2.5 +/- 6 nmol/l, and did not increase after VF. The histamine level in CS was 1.1 +/- 0.2 nmol/l before VF (p < 0.008 compared to arterial), and increased to 2.5 +/- 0.6 nmol/l immediately after (p < 0.045 compared to basal), to 3 +/- 1.1 nmol/l 2 min after (p < 0.45), and to 2.4 +/- 0.8 nmol/l 5 min after VF. In the basal state there was an uptake of histamine across the coronary circulation. After VF/DEF the level of histamine increased in coronary venous blood, suggesting cardiac release of histamine.

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Citations

Sep 23, 1998·Pacing and Clinical Electrophysiology : PACE·U F WolfhardM Günnicker
Jan 1, 1997·Scandinavian Cardiovascular Journal : SCJ·G ValenJ Vaage
Mar 24, 1998·Journal of Cardiothoracic and Vascular Anesthesia·M RunsiöL Jorfeldt

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