Abstract
Histamine has inotropic, chronotropic, arrhythmogenic, and vasoactive effects, and is released from the heart in ischaemia-reperfusion injury. The effect of ventricular fibrillation (VF) and defibrillation (DEF) on histamine release was investigated in 9 anaesthetized patients undergoing transvenous implantation of ICD. Concomitant arterial and coronary sinus (CS) blood samples were drawn before induction of VF (duration 20 seconds), immediately after, and 2 and 5 min after DEF (18-24 Joules). Basal arterial histamine was 2.5 +/- 6 nmol/l, and did not increase after VF. The histamine level in CS was 1.1 +/- 0.2 nmol/l before VF (p < 0.008 compared to arterial), and increased to 2.5 +/- 0.6 nmol/l immediately after (p < 0.045 compared to basal), to 3 +/- 1.1 nmol/l 2 min after (p < 0.45), and to 2.4 +/- 0.8 nmol/l 5 min after VF. In the basal state there was an uptake of histamine across the coronary circulation. After VF/DEF the level of histamine increased in coronary venous blood, suggesting cardiac release of histamine.
References
Apr 15, 1979·Analytical Biochemistry·R E Shaff, M A Beaven
Feb 1, 1991·Journal of the American College of Cardiology·M J Kern
May 1, 1991·Agents and Actions·H SitterJ Sattler
Feb 1, 1991·The Journal of Allergy and Clinical Immunology·R R SchellenbergR E Rangno
Feb 1, 1991·Journal of the American College of Cardiology·K OkumuraK Obata
Apr 1, 1985·Agents and Actions·E MasiniJ P Gagnol
Jan 1, 1986·Circulation Research·A A Wolff, R Levi
Apr 1, 1986·Agents and Actions·F ZacaS Lenzi
Apr 1, 1987·Agents and Actions·E MasiniP F Mannaioni
Jun 1, 1987·Agents and Actions·S Dai
Apr 1, 1989·Agents and Actions·E MasiniP F Mannaioni
Feb 1, 1972·The American Journal of Cardiology·W Ganz, H J Swan
Nov 1, 1973·British Journal of Pharmacology·P F Mannaioni, F Moroni
Sep 1, 1982·Klinische Wochenschrift·H D RöherJ V Parkin
Sep 1, 1982·Klinische Wochenschrift·W LorenzE Neugebauer
Feb 1, 1984·Circulation·R GinsburgM E Billingham
Mar 30, 1984·Science·S Kalsner, R Richards
May 1, 1984·Japanese Journal of Medicine·F YoshimuraK Yoshida
Nov 1, 1981·American Heart Journal·R GinsburgD C Harrison
Jan 1, 1982·The American Journal of Cardiology·M R BristowD C Harrison
Sep 1, 1993·Agents and Actions·G ValenJ Vaage
Apr 1, 1994·Acta Physiologica Scandinavica·G ValenJ Vaage
Aug 1, 1994·Acta Physiologica Scandinavica·A Franco-CerecedaJ M Lundberg
Mar 1, 1994·Agents and Actions·G ValenJ Vaage
Feb 1, 1994·Chest·C AttenhoferF W Amann
Jan 1, 1993·Journal of Molecular and Cellular Cardiology·G ValenJ Vaage
Dec 1, 1995·European Heart Journal·M RunsiöA Franco-Cereceda
Dec 31, 1910·The Journal of Physiology·H H Dale, P P Laidlaw
Citations
Sep 23, 1998·Pacing and Clinical Electrophysiology : PACE·U F WolfhardM Günnicker
Jan 1, 1997·Scandinavian Cardiovascular Journal : SCJ·G ValenJ Vaage
Mar 24, 1998·Journal of Cardiothoracic and Vascular Anesthesia·M RunsiöL Jorfeldt
Nov 21, 1997·Critical Care Medicine·M RunsiöM Ingvar