Cardiac Remodeling in Chronic Kidney Disease.

Toxins
Nadine KaeslerRafael Kramann

Abstract

Cardiac remodeling occurs frequently in chronic kidney disease patients and affects quality of life and survival. Current treatment options are highly inadequate. As kidney function declines, numerous metabolic pathways are disturbed. Kidney and heart functions are highly connected by organ crosstalk. Among others, altered volume and pressure status, ischemia, accelerated atherosclerosis and arteriosclerosis, disturbed mineral metabolism, renal anemia, activation of the renin-angiotensin system, uremic toxins, oxidative stress and upregulation of cytokines stress the sensitive interplay between different cardiac cell types. The fatal consequences are left-ventricular hypertrophy, fibrosis and capillary rarefaction, which lead to systolic and/or diastolic left-ventricular failure. Furthermore, fibrosis triggers electric instability and sudden cardiac death. This review focuses on established and potential pathophysiological cardiorenal crosstalk mechanisms that drive uremia-induced senescence and disease progression, including potential known targets and animal models that might help us to better understand the disease and to identify novel therapeutics.

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Citations

Jun 18, 2020·Toxins·Heidi Noels, Joachim Jankowski
Dec 15, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gregorio Romero-GonzálezJavier Díez
Feb 11, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jakob LedwochPetra Hoppmann
Mar 27, 2021·Frontiers in Cardiovascular Medicine·Yipeng ZhangBen He
Oct 12, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Cassandra A PetriChristian Hanna

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