Cardiac Remodelling in Patients Undergoing in-Centre Nocturnal Haemodialysis: Results from the MIDNIGHT Study, a Non-Randomized Controlled Trial

Blood Purification
Matthew P M Graham-BrownJames O Burton

Abstract

Evidence suggests extended-hours haemodialysis (HD) may improve cardiovascular, medical and quality-of-life outcomes. In-centre nocturnal haemodialysis (INHD) is an established but underutilized method of providing extended-hours treatment. This 6-month, non-randomized controlled trial (ISRCTN16672784) recruited 13 INHD patients and 12 control patients on conventional HD. The effects of treatment on left ventricular (LV) structure, function and myocardial fibrosis were assessed using cardiac magnetic resonance imaging and native T1 mapping. Quality-of-life and clinical measures were also collected. INHD led to significant reductions in LV mass (-14.75 vs. +6.54 g; p = 0.02), global T1 (-30.62 vs. 0.4 ms; p = 0.05) and non-septal native T1 values (-30.93 vs. 8.96 ms; p = 0.02) over time. There were also significant improvements in serum phosphate (-0.39 vs. +0.02 mmol/L; p = 0.03) and reductions in ultrafiltration rates (-2.32 vs. +0.70 mL/h/kg p = 0.05) between INHD and controls. Six-months of INHD was associated with favourable LV remodelling and reduced myocardial fibrosis compared to patients on conventional haemodialysis.

References

Jun 22, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K AmannE Ritz
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christopher ChanAndreas Pierratos
Feb 5, 2003·Blood Purification·S AlloattiV Pellu
Dec 11, 2003·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Peter HunoldJörg Barkhausen
Jul 3, 2007·Advances in Chronic Kidney Disease·Michael V Rocco
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Bruce F CulletonBraden J Manns
Nov 16, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Christopher W McIntyrePaolo G Camici
Dec 28, 2007·Kidney International·S ElootR Vanholder
Feb 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Charles A HerzogDavid T Gilbertson
Jul 17, 2008·Seminars in Dialysis·Charles A HerzogRod Passman
Feb 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sascha DavidJan T Kielstein
Apr 3, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Ann BugejaMarc Goldstein
Apr 10, 2009·Clinical Journal of the American Society of Nephrology : CJASN·James O BurtonChristopher W McIntyre
May 28, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Joanna Ruth PowellColin C Geddes
Oct 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·James O BurtonChristopher W McIntyre
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Eduardo LacsonRaymond M Hakim
Nov 26, 2010·The New England Journal of Medicine·Glenn M ChertowAlan S Kliger
Dec 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ercan OkUNKNOWN Long Dialysis Study Group
Dec 24, 2010·Current Opinion in Nephrology and Hypertension·Eduardo Lacson, Michael Lazarus
May 13, 2011·Nephron. Clinical Practice·Robert MactierCormac Breen
May 21, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Helen J JefferiesChristopher W McIntyre
Sep 21, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francisco MaduellJosep M Campistol
Oct 12, 2011·The Journal of Clinical Investigation·Christian FaulMyles Wolf
Mar 1, 2012·Journal of the American Society of Nephrology : JASN·Gihad E NesrallahRita S Suri
Jul 24, 2012·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Xiucai JinXiaoyu Chen
Apr 20, 2013·Journal of the American Society of Nephrology : JASN·Colin D ChueCharles J Ferro
Jul 17, 2013·BMC Medical Research Methodology·Lehana ThabaneCharles H Goldsmith
Oct 10, 2013·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Christopher M KramerUNKNOWN Society for Cardiovascular Magnetic Resonance Board of Trustees Task Force on Standardized Protocols
Sep 19, 2014·Nephrology·Diana Yuan Yng ChiuDarren Green
Nov 28, 2015·Clinical Kidney Journal·Matthew P M Graham-BrownJames O Burton
Apr 15, 2016·European Heart Journal Cardiovascular Imaging·M P M Graham-BrownG P McCann
May 4, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sunil V BadveDavid W Johnson
Feb 28, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Matthew P M Graham-BrownGerry P McCann

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Citations

Aug 21, 2018·Current Opinion in Nephrology and Hypertension·James O Burton, Matthew P M Graham-Brown
Mar 7, 2020·Hemodialysis International·Katherine L HullJames O Burton
Oct 4, 2018·Current Opinion in Nephrology and Hypertension·James O Burton, Matthew P M Graham-Brown
Mar 4, 2020·International Urology and Nephrology·Lee SkeatNigel D Toussaint
Dec 19, 2020·Canadian Journal of Kidney Health and Disease·Michael E SchachterDan J Martinusen

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