Cardiac repair achieved by bone marrow mesenchymal stem cells/silk fibroin/hyaluronic acid patches in a rat of myocardial infarction model

Biomaterials
Nai-Hsin ChiShoei-Shen Wang

Abstract

Bone marrow mesenchymal stem cells/silk fibroin/hyaluronic acid (BMSC/SH) patches were implanted into myocardial infarction (MI) rat hearts to investigate the efficacies of them on enhancing left ventricular (LV) remodeling and cardiac repair. 45 rats were divided into four groups: Sham, MI (MI hearts, induced by a cryo-injury technique), SH and BMSC/SH (MI hearts with implantations of SH and BMSC/SH patches, respectively). After eight weeks of post-implantation, the patches for the SH and BMSC/SH groups were intact and well adhered on the MI zones with no and minor immunological responses, respectively, examined by a CD68 marker, while severe inflammation on the zones was observed for the MI group. The SH group showed the efficacy of cardiac repair on MI zones. Moreover, BMSC/SH group significantly improved the wall thickness of LV, assessed by echocardiography, and had high viability of delivery BMSC, largely reduced apoptosis, significantly promoted neo-vascularization and stimulated the secretions of various paracrine factors such as VEGF, examined by real-time PCR, in MI zones compared with those of the SH and MI groups. In conclusion, the therapeutic efficacies of using BMSC/SH patches for repairing MI hearts were demonst...Continue Reading

References

May 16, 2001·Mammalian Genome : Official Journal of the International Mammalian Genome Society·O HenegariuJ M Greally
May 3, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ewout J van den BosDirk J Duncker
Jul 5, 2005·Journal of Molecular and Cellular Cardiology·S VanderveldeM C Harmsen
Oct 4, 2005·Journal of the American College of Cardiology·Yao Liang TangM Ian Phillips
Jan 24, 2006·Seminars in Thoracic and Cardiovascular Surgery·James A Magovern
Apr 4, 2006·Nature Medicine·Yoshinori MiyaharaHidezo Mori
Jul 15, 2009·Biochemical and Biophysical Research Communications·Ryo SuzukiKeiichi Fukuda
Mar 25, 2010·BMC Molecular Biology·Trond BrattelidKristin B Andersson
Apr 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Frederic TreguerFabrice Prunier
May 4, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alain J PonceletPierre Gianello
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jamie L IfkovitsJason A Burdick
Oct 30, 2010·Indian Journal of Human Genetics·Reena TanjorePratibha Nallari

❮ Previous
Next ❯

Citations

Dec 29, 2012·International Journal of Nanomedicine·Rajeswari RavichandranSeeram Ramakrishna
Mar 19, 2014·Tissue Engineering. Part C, Methods·Cristina Martínez-RamosManuel Monleón Pradas
Feb 20, 2016·International Journal of Biological Macromolecules·Mahadevappa HemshekharKesturu S Girish
Dec 17, 2015·Stem Cell Research & Therapy·Isaac Perea-GilAntoni Bayes-Genis
Nov 2, 2014·Journal of Biomedical Science·Francesca BonafèClaudio Muscari
Jun 2, 2015·Frontiers in Bioengineering and Biotechnology·Shane Browne, Abhay Pandit
Jan 15, 2015·Cardiovascular Drugs and Therapy·Vanessa-leigh van ZuylenDouwe E Atsma
Sep 10, 2016·Expert Opinion on Biological Therapy·Bora Nadlacki, Erik J Suuronen
Nov 22, 2017·Journal of Tissue Engineering and Regenerative Medicine·Hsin-Yu LoShoei-Shen Wang
Aug 24, 2017·Biomaterials Science·Ambigapathi MoorthiTze-Wen Chung
Jul 7, 2018·Circulation Research·Jianyi ZhangGordana Vunjak-Novakovic
Oct 12, 2013·Journal of the American Heart Association·Rebecca D LevitW Robert Taylor
Sep 18, 2020·Advanced Healthcare Materials·Yu SongLin Wang
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Qasim A MajidIpsita Roy
Feb 17, 2021·ACS Biomaterials Science & Engineering·Luis Eduardo Portillo Esquivel, Boyang Zhang
Apr 5, 2017·Biomaterials·Nicole R RaiaDavid L Kaplan
Mar 16, 2016·Biotechnology Advances·Mohammadmajid SepantafarHossein Baharvand
Mar 16, 2021·Frontiers in Cardiovascular Medicine·Lu WangJianyi Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.