Cardiac repolarization variability in patients with postural tachycardia syndrome during graded head-up tilt

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Mathias BaumertEugene Nalivaiko

Abstract

The aim of this study was to assess cardiac ventricular repolarization in patients with postural tachycardia syndrome (POTS) and further the possible link between ventricular repolarization and sympathetic nervous system activity. We recorded body surface ECGs together with plasma noradrenaline (NE) spillover, and muscle sympathetic nerve activity (MSNA) in twelve healthy control subjects (CON; 5 males; age: 23±2 yrs) and 13 subjects with postural tachycardia syndrome (POTS; 4 males; 32±13 yrs) during graded head-up tilt (0°-20°-30°-40°). Ventricular repolarization was assessed by computing various measures of beat-to-beat QT interval variability and T wave amplitude. In patients with POTS, baseline heart rates were higher and MSNA increases during tilt were more pronounced than in CON. None of the QT variability measures was significantly affected by tilt or different between CON and POTS when corrected for heart rate. Contrary, the T wave amplitude flattened due to tilt (p<0.001) and this effect was significantly more pronounced in POTS (32% at 40°) than in CON (21% at 40°; p=0.03). Beat-to-beat variability of the QT interval is normal in patients with POTS. However, significantly more attenuated T waves during head-up tilt t...Continue Reading

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Citations

Jul 24, 2012·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Muhammad A HasanMathias Baumert
Jan 30, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mathias BaumertPaul G A Volders
Aug 23, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ramya VajapeyKenneth A Mayuga
Mar 1, 2020·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Yuwen WangCheng Wang
Mar 25, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andrea MarchiAlberto Porta
Aug 16, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Fatima El-HamadMathias Baumert

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