Cardiac Resynchronization Therapy May Be Antiarrhythmic Particularly in Responders: A Systematic Review and Meta-Analysis.

JACC. Clinical Electrophysiology
Aditya SainiPaari Dominic

Abstract

This study sought to study the effect of echocardiographic response to cardiac resynchronization therapy (CRT) on ventricular arrhythmias (VA). The effect of CRT-defibrillator on sustained VA was compared with implantable cardioverter-defibrillator (ICD)-only therapy. CRT is an effective adjunctive therapy in selected patients with advanced congestive heart failure, but its effect on VA remains controversial. PubMed was searched to identify studies. For primary comparison, studies reporting incidence of VA in patients with congestive heart failure with CRT compared with ICD were included. For secondary comparison, studies reporting incidence of VA in echocardiographic responders compared with nonresponders were included. Studies reporting incidence of VA in CRT nonresponders before and after CRT upgrade from ICD were assessed for the third comparison. Inverse variance method in a random-effects model was used to combine effect sizes. Thirteen studies (4,631 subjects) were included in the primary meta-analysis. Patients with CRT had a significantly lower incidence of VA compared with patients with ICD only (odds ratio: 0.754; confidence interval: 0.594 to 0.959). Thirteen studies (n = 3,667) were included in the meta-analysis of...Continue Reading

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Citations

Jun 17, 2018·Journal of the American Heart Association·Rakesh GopinathannairMark S Slaughter
Aug 15, 2018·Journal of Cardiovascular Electrophysiology·Yixiu LiangJunbo Ge
Oct 31, 2018·Frontiers in Physiology·Daniel M Johnson, Gudrun Antoons
Jan 27, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Matthew F YuyunJagmeet P Singh

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