PMID: 11923041Mar 30, 2002Paper

Cardiac resynchronization therapy restores optimal atrioventricular mechanical timing in heart failure patients with ventricular conduction delay

Journal of the American College of Cardiology
A AuricchioHelmut U Klein

Abstract

We characterized the relationship between systolic ventricular function and left ventricular (LV) end-diastolic pressure (LVEDP) in patients with heart failure (HF) and baseline asynchrony during ventricular stimulation. The role of preload in the systolic performance improvement that can be obtained in HF patients with LV stimulation is uncertain.We measured the maximum rate of increase of LV pressure, LVEDP, aortic pulse pressure (PP) and the atrioventricular mechanical latency (AVL) between left atrial systole and LV pressure onset in 39 patients with HF. Two subgroups were identified: "responder" if PP improved, or "nonresponder."Maximum hemodynamic improvement occurred at an atrioventricular (AV) delay that did not decrease LVEDP. Left ventricular and biventricular (BV) stimulation increased systolic hemodynamics significantly, despite no significant increase in LVEDP. All parameters decreased when the LVEDP was decreased by shorter AV delay. Left ventricular and BV stimulation provided better hemodynamics than right ventricular (RV) stimulation. For the nonresponder subgroup, systolic hemodynamics only worsened during AV delay shortening. For the responder subgroup, optimum PP was achieved when AVL was near zero. Restorat...Continue Reading

References

Feb 1, 1997·Pacing and Clinical Electrophysiology : PACE·A Auricchio, R W Salo
May 23, 1997·International Journal of Cardiology·L SpinarovaT Kara
Mar 22, 2001·The New England Journal of Medicine·S CazeauUNKNOWN Multisite Stimulation in Cardiomyopathies (MUSTIC) Study Investigators
Oct 5, 2001·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·J A Salerno-Uriarte, M Tritto
Dec 12, 2001·Journal of the American College of Cardiology·C StellbrinkUNKNOWN PATH-CHF (PAcing THerapies in Congestive Heart Failure) Investigators; CPI Guidant Congestive Heart Failure Research Group
Dec 19, 2001·Circulation·C ButterUNKNOWN Pacing Therapy for Chronic Heart Failure II Study Group

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Citations

Mar 20, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Patrick T SiegristPhilipp A Kaufmann
Mar 12, 2008·Herzschrittmachertherapie & Elektrophysiologie·A KloppeM Zarse
Aug 13, 2009·Herzschrittmachertherapie & Elektrophysiologie·M KindermannG Fröhlig
Sep 24, 2005·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Christian Perzanowski, F Roosevelt Gilliam
Dec 24, 2005·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·I Eli Ovsyshcher
Aug 10, 2002·Current Cardiology Reports·Silke Isabelle TrautmannAngelo Auricchio
Jul 24, 2008·Current Treatment Options in Cardiovascular Medicine·Ayesha Hasan, William T Abraham
Aug 8, 2013·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·A GhaniP P H M Delnoy
Aug 9, 2003·Journal of the American College of Cardiology·Xander A A M VerbeekFrits W Prinzen
Mar 29, 2006·Nature Clinical Practice. Cardiovascular Medicine·Gabe B BleekerErnst E van der Wall
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Hung-Fat TseChu-Pak Lau
Aug 30, 2008·European Heart Journal·Tony StantonJohn J V McMurray
May 22, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Peter Paul DelnoyGianni Plicchi
Nov 5, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·S Serge BaroldBengt Herweg
Sep 16, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Jagmeet P SinghAndrew Kaplan
Nov 3, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Radu VatasescuJosep Brugada
Nov 17, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fakhar Z KhanDavid P Dutka
Jun 8, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·José M DizonHasan Garan
Feb 9, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Lanfranco AntoniniMassimo Santini
May 3, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Philippe RitterJorge Silvestre
Feb 28, 2006·Heart·Frank A Flachskampf, Jens-Uwe Voigt
May 17, 2007·Clinical Drug Investigation·William S WeintraubRoland S Chen
Aug 7, 2009·Future Cardiology·Avi Fischer
Jul 4, 2013·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M M D MolenaarJ M van Opstal
Nov 2, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mary M MaleckarKirstine Calloe
Nov 19, 2013·International Journal of Cardiology·UNKNOWN International Working Group on Quantitative Optimization:Darrel P Francis
May 29, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Andrew BrenyoIlan Goldenberg
Dec 10, 2015·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·B M van GelderF A Bracke
Jul 28, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Ayesha Hasan
May 26, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Nana ValeurPeter Søgaard
Sep 4, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kenneth M Stein

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