Cardiac retention of [11C]HED in genotyped long QT patients: a potential amplifier role for severity of the disease

American Journal of Physiology. Heart and Circulatory Physiology
Alejandro N MazzadiMarc Janier

Abstract

Although mutations in cardiac sodium and potassium channel genes are associated with congenital long QT syndrome (LQTS), a "modifier" role of the sympathetic nervous system was proposed to explain the distinct severity of the disease. We evaluated cardiac sympathetic innervation using [11C]hydroxyephedrine ([11C]HED) and positron emission tomography (PET) in genotyped LQTS patients. H215O and [11C]HED PET studies were performed in 11 patients (5 symptomatic) and 8 controls. Perfusion and [11C]HED images were depicted as 36-sector polar maps. Sectorial values of perfusion (H2O%), absolute (HEDRet) and relative retention (HED%Ret) of [11C]HED, and the ratio of HED%Ret to H2O% (HED%Ret/H2O%) were calculated. Normal databases were obtained from controls. Sectorial values below 2SD database values were defined as "outside sectors." Controls and patients showed similar sectorial perfusion. Sectorial HEDRet did not differ between groups, but means of HED%Ret were lower in three sectors for patients (P < 0.05). Three sectors from 3 controls had HED%Ret below 2SD, whereas 36 sectors in 9 patients were outside sectors (P < 0.01). In patients, average HED%Ret/H2O% was lower in 9 sectors (P < 0.05 vs. controls); 2 outside sectors were foun...Continue Reading

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Citations

May 18, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alejandro N MazzadiPhilippe Chevalier
May 5, 2007·European Journal of Nuclear Medicine and Molecular Imaging·Riikka LautamäkiFrank M Bengel
Jun 22, 2011·European Journal of Nuclear Medicine and Molecular Imaging·Peter KiesEric Schulze-Bahr
Nov 28, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James T Thackeray, Frank M Bengel
Dec 17, 2015·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mischa T RijniersePaul Knaapen
Dec 3, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Osamu ManabeKeiichiro Yoshinaga
Oct 8, 2009·Circulation. Cardiovascular Imaging·Alejandro N MazzadiPhilippe Chevalier
Dec 10, 2003·Current Cardiology Reports·Robert J Gropler, Pablo Soto
Jun 3, 2015·Nuclear Medicine Communications·Ismet Sarikaya
Jun 3, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rasmus Borgquist, Jagmeet P Singh

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