PMID: 22563720May 9, 2012Paper

Cardiac side effects of chemotherapy: state of art and strategies for a correct management

Current Vascular Pharmacology
Cinzia PerrinoGiovanni Esposito

Abstract

In recent years, the development of more effective drugs has provided a better prognosis and an increase in life expectancy for patients at all-stages of cancer. On the other hand, the price for the improving effectiveness of therapies against malignant tumors is the development of severe and potentially life-threatening drug reactions. Among these, cardiac toxic effects have recently gained particular attention. The term cardiotoxicity includes many possible pathological manifestations, but the most frequent is the reduction in cardiac function, potentially leading to heart failure and death. Importantly, the development of cardiac dysfunction may occur immediately after drug administration, or after years. The purpose of this review is to discuss the clinical features of cardiotoxicity, its molecular basis and novel possible strategies to reduce the likelihood of serious cardiac complications.

Citations

Nov 26, 2015·Journal of Molecular and Cellular Cardiology·Gabriele G Schiattarella, Joseph A Hill
Nov 26, 2015·Annals of Vascular Surgery·Kun Tae AhnMasaaki Toyama
Jan 18, 2017·Biotechnology Journal·Kathrin Halfter, Barbara Mayer
Sep 11, 2018·Journal of Cancer Research and Therapeutics·Bugrahan EmsenAbdullah Kaya
Oct 10, 2019·Anais Da Academia Brasileira De Ciências·Bugrahan EmsenHasan Turkez
Jul 28, 2017·Laboratory animal research·Sou Hyun KimYoung-Suk Jung
Jan 9, 2021·Current Oncology Reports·Alexandra E TengEric H Yang

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