Cardiac status after childhood growth hormone treatment of Turner syndrome

The Journal of Clinical Endocrinology and Metabolism
Jochem van den BergWillem A Helbing

Abstract

In Turner syndrome (TS), GH treatment is well established. Data on cardiac status after discontinuation of treatment are scarce. This study aimed to assess biventricular size and function in TS at least 6 months after discontinuation of GH treatment. TS patients and healthy women prospectively underwent cardiac magnetic resonance imaging. Ventricular two-dimensional tomographic cine data were acquired to obtain biventricular volume, mass, and ejection fraction. Atrioventricular valve flow measurements were performed using a two-dimensional flow-sensitized sequence. Flow velocity curves were calculated and indices of biventricular diastolic filling were derived. Thirty-one patients [mean (sd) age 20 (2) yr, body surface area 1.75 (0.15) m(2), 5 (2) yr after GH discontinuation] and 23 normal control women [age 21 (2) yr, body surface area 1.80 (0.13) m(2)] were included. Compared with controls, patients had smaller mean end-diastolic volumes [right ventricle (RV), 84 (11) ml/m(2) vs. 79 (10), P = 0.02; left ventricle (LV), 81 (10) vs. 72 (9), P < 0.001], end-systolic volumes [RV 38 (7) ml/m(2) vs. 36 (6), P = 0.04; LV 34 (5) vs. 29 (4), P < 0.001], and stroke volumes [RV 46 (6) ml/m(2) vs. 43 (6), P = 0.03; LV, 47 (7) vs. 44 (4),...Continue Reading

References

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May 27, 2006·The American Journal of Cardiology·Jochem van den BergWillem A Helbing
May 23, 2007·The Journal of Pediatrics·Lea Ann MaturaCarolyn A Bondy

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Citations

Mar 5, 2013·PloS One·Katya De GrooteDaniel De Wolf
Nov 16, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Antoine Fakhry AbdelMassihMohamed Samir
Jun 19, 2012·Endocrine Reviews·Kristian H MortensenClaus H Gravholt
Jan 1, 2008·Expert Review of Endocrinology & Metabolism·Kateri McCarthy, Carolyn A Bondy
Nov 6, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Kamil DyrkaMarek Niedziela
Jun 1, 2020·Current Pharmaceutical Design·Eirini KostopoulouDimitrios G Goulis
Mar 24, 2010·Pediatrics·Judith RossUNKNOWN advisory panel meeting on the effects of growth hormone

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