Cardiac Structural Remodeling, Longitudinal Systolic Strain, and Torsional Mechanics in Lean and Nonlean Dysglycemic Chinese Adults

Circulation. Cardiovascular Imaging
Jiun-Lu LinCarolyn S P Lam

Abstract

Diabetes mellitus and pre-diabetes mellitus are associated with lower body mass indices and increased risk of cardiovascular events (including heart failure) at lower glucose thresholds in Chinese compared with Western cohorts. However, the extent of cardiac remodeling and regulation on cardiac mechanics in lean and nonlean dysglycemic Chinese adults is understudied. We studied 3950 asymptomatic Chinese (aged 49.7±10.7 years; 65% male; body mass index: 24.3±3.5 kg/m2) with comprehensive echocardiography including speckle tracking for left ventricular global longitudinal strain/torsion, with plasma sugar, glycosylated hemoglobin (HbA1c), and insulin resistance (homeostasis model assessment of insulin resistance) obtained. Participants were classified as (1) nondiabetic (fasting glucose <100 mg/mL; HbA1c <5.7%; n=1416), prediabetic (fasting glucose 100-126 mg/dL; HbA1c 5.7%-6.4%; n=2029), or diabetic (n=505) and (2) lean (body mass index <23 kg/m2; n=1445) or nonlean (n=2505). Higher sugar, HbA1c, and homeostasis model assessment of insulin resistance were independently associated with higher left ventricular mass, greater mass-to-volume ratio, more impaired diastolic indices, and worse global longitudinal strain even after adjus...Continue Reading

References

Jul 16, 1999·Clinical and Experimental Pharmacology & Physiology·H ItohK Nakao
Apr 20, 2001·The American Journal of the Medical Sciences·M A Alpert
Nov 14, 2006·Lancet·Kun-Ho YoonHo-Young Son
May 16, 2009·JACC. Cardiovascular Imaging·Iris K RüsselAlbert C van Rossum
Aug 6, 2010·European Journal of Heart Failure·Carolyn S P LamRamachandran S Vasan
Feb 23, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Victor Mor-AviJosé Luis Zamorano
Nov 21, 2012·Nature Reviews. Endocrinology·Vasanti S MalikFrank B Hu
Mar 19, 2013·Journal of the American College of Cardiology·Ravi V ShahMichael Jerosch-Herold
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Apr 9, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Xiaoling ZhangHong Tang
Jun 25, 2013·Diabetes Technology & Therapeutics·Viknesh Prabu AnbalaganViswanathan Mohan
Aug 14, 2013·European Journal of Endocrinology·Leontine E H BakkerIngrid M Jazet
Feb 11, 2014·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Laura ErnandeGeneviève Derumeaux
May 20, 2015·World Journal of Diabetes·Amrutha Mary GeorgeLeon Fogelfeld
Oct 21, 2016·JAMA Cardiology·Lijing L YanCarolyn S P Lam
Oct 21, 2016·JAMA Cardiology·Fiona BraggUNKNOWN China Kadoorie Biobank (CKB) Collaborative Group
Sep 19, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Chung-Lieh HungCarolyn S P Lam
Jun 10, 2017·Journal of the American College of Cardiology·Yau-Huei LaiCarolyn S P Lam

❮ Previous
Next ❯

Citations

Dec 5, 2019·European Heart Journal·Carolyn S P LamAdriaan A Voors
Jun 3, 2020·European Journal of Heart Failure·Amy GroenewegenArno W Hoes
Sep 21, 2020·The International Journal of Cardiovascular Imaging·Adem AticiTufan Tukek
Nov 15, 2020·Echocardiography·Tahereh Davarpasand, Ali Hosseinsabet

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.