Cardiac structure and function and insulin resistance in morbidly obese patients: does superobesity play an additional role?

Cardiology
Francesco Antonini-CanterinBogdan A Popescu

Abstract

To evaluate the impact of superobesity, defined as body mass index (BMI) ≥50, on cardiac structure and function. Using echocardiography, we studied 198 asymptomatic patients (mean age 48 ± 13 years, 29.3% were men) with a BMI ≥40. Insulin resistance was measured using the Homeostasis Model Assessment of insulin resistance (HOMA-IR). Patients were divided into 2 groups: morbidly obese (BMI ≥40 and <50; n = 160) and superobese (BMI ≥50; n = 38). There were no significant differences in age, gender, hypertension and diabetes between groups. Superobese patients had higher LV mass (66.0 ± 14.7 vs. 59.9 ± 11.9 g/m(2.7), p = 0.007), left ventricular (LV) end-diastolic (33.8 ± 7.7 vs. 31.5 ± 7.1 ml/m(2.7), p = 0.041) and end-systolic (12.2 ± 3.6 vs. 10.9 ± 2.8 ml/m(2.7), p = 0.016) volumes, left atrial volume (13.8 ± 4.5 vs. 12.2 ± 3.9 ml/m(2.7), p = 0.029), peak velocity of transmitral flow in early diastole/early diastolic peak myocardial velocity ratio (9.1 ± 2.6 vs. 8.2 ± 2.2, p = 0.03) and HOMA-IR (9.7 ± 7.3 vs. 7.3 ± 6.5, p = 0.047). LV ejection fraction was similar. Superobesity is associated with insulin resistance and a worse impact on cardiac remodeling and LV diastolic function than morbid obesity. Prospective studies are ne...Continue Reading

Citations

Feb 13, 2016·Metabolic Syndrome and Related Disorders·Salvatore La CarrubbaVitantonio Di Bello
Sep 10, 2015·Hypertension·Ernesto Martínez-MartínezVictoria Cachofeiro
Aug 15, 2015·European Journal of Pediatrics·M L MarcovecchioG Renda
May 23, 2014·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·P CreaS Carerj
May 24, 2019·Journal of Translational Medicine·Antonino De LorenzoLaura Di Renzo
Apr 16, 2020·Obesity Surgery·Tze Wei Wilson YangWendy A Brown

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