Cardiac structure and function in adolescent Sherpa; effect of habitual altitude and developmental stage

American Journal of Physiology. Heart and Circulatory Physiology
Mike StembridgeRob Shave

Abstract

The purpose of this study was to examine ventricular structure and function in Sherpa adolescents to determine whether age-specific differences in oxygen saturation (SpO2 ) and pulmonary artery systolic pressure (PASP) influence cardiac adaptation to chronic hypoxia early in life. Two-dimensional, Doppler, and speckle-tracking echocardiography were performed on adolescent (9-16 yr) highland Sherpa (HLS; 3,840 m; n = 26) and compared with age-matched lowland Sherpa (LLS; 1,400 m; n = 10) and lowland Caucasian controls (LLC; sea level; n = 30). The HLS were subdivided into pre- and postadolescence; SpO2 was also recorded. Only HLS exhibited a smaller relative left ventricular (LV) end-diastolic volume; however, both HLS and LLS demonstrated a lower peak LV untwisting velocity compared with LLC (92 ± 26 and 100 ± 45 vs. 130 ± 43°/s, P < 0.05). Although SpO2 was similar between groups, PASP was higher in post- vs. preadolescent HLS (30 ± 5 vs. 25 ± 5 mmHg, P < 0.05), which negatively correlated with right ventricular strain rate (r = 0.50, P < 0.01). Much like their adult counterparts, HLS and LLS adolescents exhibit slower LV diastolic relaxation, despite residing at different altitudes. These findings suggest fundamental differen...Continue Reading

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Citations

Jan 7, 2017·High Altitude Medicine & Biology·Jeffrey C RobinsonTodd M Bull
Mar 16, 2019·Journal of the American Heart Association·Congyi ZhengZengwu Wang
May 20, 2017·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Jan GrimmingerHossein Ardeschir Ghofrani
Jan 19, 2021·Journal of the American Heart Association·Congyi ZhengZengwu Wang
Sep 22, 2021·Journal of Developmental Origins of Health and Disease·Mayra Asas-Jinde, Fabricio González-Andrade

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