PMID: 1195018Dec 1, 1975Paper

Cardiac structure and function in vitamin B-12-deprived rats

The Journal of Nutrition
B J Petersen, G V Vahouny

Abstract

The effect of prolonged vitamin B-12 deprivation in rats on the histological structure of heart and on cardiac linoleic acid oxidation has been investigated. Offspring from pregnant females fed vitamin B-12-deficient diets were fed the deprivation diet for up to 16 months, and the development of B-12 deficiency was monitored by determination of urinary methylmalonic acid levels. These levels averaged 4.2 mg/day by 9 months of B-12-deprivation diet, and 142 mg/day after 16 months. The hearts of these animals were characterized by extensive fibrosis, and electron microscopy revealed cardiac mitochondria that were grossly enlarged and distorted. The metabolic defect of B-12 deprivation in heart muscle was determined in isolated hearts during recirculating perfusion of labeled propionic acid. Both the uptake and oxidation of propionic acid were markedly reduced in hearts from B-12-deprived rats (16 months) compared with controls, and the site of the metabolic block, i.e., accumulation of labeled methylmalonate, was established. Vitamin B-12 deprivation did not affect the extraction of recirculating labeled linoleic acid by perfused hearts, in contrast to the effect on propionic extraction. Furthermore, the oxidation of the extracte...Continue Reading

Citations

May 1, 1978·The British Journal of Nutrition·C FehlingA Brun
Jul 1, 1983·Journal of Comparative Pathology·C A MaltinA B Wilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.