Cardiac Surgery-Associated Kidney Injury in Children and Renal Oximetry

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Rachel JoffeCatherine Morgan

Abstract

Cardiac surgery-associated acute kidney injury is common in children and associates with negative outcomes. Novel interventions to reduce cardiac surgery-associated acute kidney injury require knowledge of its pathophysiology. States of altered perfusion, oxygen delivery, and energy consumption occur during cardiopulmonary bypass and could protect against or contribute to renal cellular injury and recovery. Near-infrared spectroscopy is noninvasive technology for monitoring regional blood flow and tissue oxygenation. This study evaluated the relationship between renal regional oxygen saturation and cardiac surgery-associated acute kidney injury, using near-infrared spectroscopy monitoring before, during, and after cardiopulmonary bypass in children. Prospective cohort study. Single-center, tertiary care pediatric hospital (Stollery Children's Hospital, Edmonton, AB, Canada). Children less than or equal to 10 kg undergoing congenital heart disease repair with cardiopulmonary bypass. Heart transplant, preoperative dialysis, sepsis, extracorporeal life support, congenital renal disease, and preoperative nephrotoxins were exclusions. Renal regional near-infrared spectroscopy monitoring before, during, and after cardiopulmonary bypa...Continue Reading

References

Feb 13, 2001·Journal of Applied Physiology·M C Van BeekveltB G Van Engelen
Jun 9, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Frans B PlötzJoanna A E van Wijk
Jul 4, 2006·Physiological Reviews·Volker VallonHartmut Osswald
Mar 31, 2007·Kidney International·A Akcan-ArikanS L Goldstein
Oct 20, 2007·Acta Anaesthesiologica Scandinavica·K R PedersenV E Hjortdal
May 31, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Roland SchmittChirag R Parikh
Apr 7, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Steven G CocaChirag R Parikh
Apr 30, 2010·Contributions to Nephrology·Joseph V Bonventre
Jul 2, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael ZappitelliStuart L Goldstein
Dec 21, 2010·Surgical Neurology International·Erin A BoothMichael Wider
Apr 29, 2011·Kidney International·Michael ZappitelliUNKNOWN TRIBE-AKI consortium
Aug 13, 2011·Journal of the American Society of Nephrology : JASN·Chirag R ParikhUNKNOWN TRIBE-AKI Consortium
Aug 11, 2012·The Journal of Pediatrics·Catherine J MorganUNKNOWN Western Canadian Complex Pediatric Therapies Follow-Up Group
Nov 2, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jill VanmassenhoveWim Van Biesen
Oct 1, 2011·World Journal for Pediatric & Congenital Heart Surgery·Colby ColasaccoRobert Spear
Sep 7, 2016·Scandinavian Cardiovascular Journal : SCJ·Vesa AnttilaTatu Juvonen
Sep 13, 2016·JAMA Pediatrics·Jason H GreenbergUNKNOWN TRIBE-AKI Consortium

❮ Previous
Next ❯

Citations

Nov 6, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jeffrey S Isenberg, David D Roberts
Jul 12, 2020·Pediatric Surgery International·Emine ÇalışkanBaran Tokar
Jun 20, 2020·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Marco ModestiniThomas W L Scheeren
Feb 2, 2021·The Annals of Thoracic Surgery·Yan ZhangRong-Hua Zhou
Feb 14, 2021·The Annals of Thoracic Surgery·Peiyao ZhangJinxiao Hu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.