Cardiac sympathetic degeneration correlates with olfactory function in Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Mutsumi IijimaShinichiro Uchiyama

Abstract

Autonomic and olfactory dysfunctions are considered markers for preclinical diagnosis in Parkinson's disease (PD), because pathological changes in these systems can start before motor symptoms develop. We investigated whether cardiac sympathetic function and olfactory function are associated in PD. Participants comprised 40 nondemented patients with idiopathic PD, and age-matched controls. Cardiac sympathetic function was evaluated by (123) I-metaiodobenzylguanidine (MIBG) uptake, in terms of the heart to mediastinum (H/M) ratio in both early and delayed images, and the washout rate (WR). Olfactory function was evaluated using the Odor Stick Identification Test for Japanese, which evaluates the detection of 12 odorants familiar to Japanese participants. Smell identification scores were significantly lower (P < 0.001) in patients with PD than in controls. Smell identification scores correlated positively with early (P < 0.05) and delayed H/M ratios (P < 0.01), and inversely with the WR (P < 0.005) especially in patients with early PD (below 5 years of the start of motor symptoms), whereas smell identification scores did not correlate with any parameters of MIBG in the advanced PD (above 5 years of the start of motor symptoms). T...Continue Reading

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Feb 9, 2012·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Peter KangSamay Jain
Jul 30, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M IijimaS Uchiyama
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May 26, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Javier Ruiz-MartínezJosé F Martí Massó
May 26, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·James F MorleyJohn E Duda
Apr 18, 2021·Parkinsonism & Related Disorders·Nobuyuki ArakiMasato Asahina
Nov 13, 2019·Neuro-degenerative Diseases·Tokunori IkedaSatoshi Yamashita

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